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clcnkb.L chloride channel, voltage-sensitive Kb L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378616, updated on 4-Nov-2024

Summary

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Official Symbol
clcnkb.L
Official Full Name
chloride channel, voltage-sensitive Kb L homeolog
Primary source
Xenbase:XB-GENE-6252397
Locus tag
XELAEV_18036392mg
See related
EnsemblRapid:ENSXLAG00005016451 AllianceGenome:Xenbase:XB-GENE-6252397
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ClC-k; clckb; clc-kb; clcnka; clcnkb; clk-k2; x6clck; xCIC-K; xClC-K; clcnka-A
Summary
Predicted to enable chloride channel activity. Predicted to act upstream of or within chloride transport. Located in plasma membrane. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in Bartter disease type 3; Bartter disease type 4b; Gitelman syndrome; and hypertension. Orthologous to human CLCNKB (chloride voltage-gated channel Kb). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See clcnkb.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (137629661..137652405, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (119783482..119806560)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene EPH receptor A2 L homeolog Neighboring gene protein FAM131C Neighboring gene heat shock protein family B (small) member 7 L homeolog Neighboring gene serine/threonine-protein kinase N2-like Neighboring gene zinc finger and BTB domain containing 17 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A synthetic prostone activates apical chloride channels in A6 epithelial cells. Bao HF, et al. Am J Physiol Gastrointest Liver Physiol, 2008 Aug. PMID 18511742, Free PMC Article
  2. Expression and targeting to the plasma membrane of xClC-K, a chloride channel specifically expressed in distinct tubule segments of Xenopus laevis kidney. Maulet Y, et al. Biochem J, 1999 Jun 15. PMID 10359659, Free PMC Article
  3. Probing the Xenopus laevis inner ear transcriptome for biological function. Powers TR, et al. BMC Genomics, 2012 Jun 8. PMID 22676585, Free PMC Article
  4. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC82020

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chloride transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chloride channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chloride channel protein ClC-Kb
Names
chloride channel Ka

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085839.1 → NP_001079308.1  chloride channel protein ClC-Kb

    See identical proteins and their annotated locations for NP_001079308.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ011385
    UniProtKB/Swiss-Prot
    Q9W701
    UniProtKB/TrEMBL
    A0A974HCZ5, Q6AX86
    Related
    ENSXLAP00005048512.1, ENSXLAT00005049633.1
    Conserved Domains (3) summary
    cd03683
    Location:50 → 536
    ClC_1_like; ClC-1-like chloride channel proteins. This CD includes isoforms ClC-0, ClC-1, ClC-2 and ClC_K. ClC-1 is expressed in skeletal muscle and its mutation leads to both recessively and dominantly-inherited forms of muscle stiffness or myotonia. ClC-K is ...
    cd04591
    Location:567 → 681
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:103 → 515
    Voltage_CLC; Voltage gated chloride channel

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137629661..137652405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W701.1 GenPept UniProtKB/Swiss-Prot:Q9W701

Gene LinkOut

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