kcnd3.L potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: kcnd3.L
Official Full Name: potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog
Primary source: Xenbase:XB-GENE-5867986
Locus tag: XELAEV_18012354mg
See related: EnsemblRapid:ENSXLAG00005027980 AllianceGenome:Xenbase:XB-GENE-5867986
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: kcnd3; kv4.3; xKv4.3; K(v)4.3; kcnd3-A
Summary: Predicted to enable A-type (transient outward) potassium channel activity. Predicted to act upstream of or within potassium ion export across plasma membrane and protein homooligomerization. Predicted to be located in dendritic spine; neuronal cell body; and postsynaptic membrane. Predicted to be part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2L	NC_054373.1 (78646500..78888971)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2L	NC_030726.1 (73240253..73483263)

Chromosome 2L - NC_054373.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data demonstrate isoform-specific regulation of closed-state inactivation by protein kinase C in Kv4.3
Title: Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.
biophysical 11-state Markov model of Kv4.3 gating incorporating a direct transition from the open-inactivated state to the closed-inactivated state
Title: Time- and voltage-dependent components of Kv4.3 inactivation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables A-type (transient outward) potassium channel activity	IEA Inferred from Electronic Annotation more info
enables potassium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion export across plasma membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog

Names: potassium voltage-gated channel, Shal-related subfamily, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085818.1 → NP_001079287.1 potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog precursor

See identical proteins and their annotated locations for NP_001079287.1

Status: PROVISIONAL

Source sequence(s)

U89265

UniProtKB/TrEMBL

O57662

Related

ENSXLAP00005083196.1, ENSXLAT00005084834.1

Conserved Domains (6) summary

smart00225
Location:42 → 139

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam00520
Location:217 → 417

Ion_trans; Ion transport protein

pfam02214
Location:42 → 131

BTB_2; BTB/POZ domain

pfam07885
Location:332 → 402

Ion_trans_2; Ion channel

pfam11601
Location:3 → 28

Shal-type; Shal-type voltage-gated potassium channels

pfam11879
Location:447 → 569

DUF3399; Domain of unknown function (DUF3399)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

78646500..78888971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041580827.1 → XP_041436761.1 potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog isoform X1

UniProtKB/TrEMBL

B7ZRQ9

Conserved Domains (3) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:186 → 412

Ion_trans; Ion transport protein

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)
XM_041580828.1 → XP_041436762.1 potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog isoform X2

UniProtKB/TrEMBL

A0A8J1M4Z1

Related

ENSXLAP00005083250.1, ENSXLAT00005084888.1

Conserved Domains (2) summary

PRK10537
Location:297 → 409

PRK10537; voltage-gated potassium channel protein

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)
XM_018244744.2 → XP_018100233.1 potassium channel, voltage gated Shal related subfamily D, member 3 L homeolog isoform X1

UniProtKB/TrEMBL

B7ZRQ9

Conserved Domains (3) summary

cd18419
Location:6 → 143

BTB_POZ_KCND3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3)

pfam00520
Location:186 → 412

Ion_trans; Ion transport protein

pfam11879
Location:442 → 563

DUF3399; Domain of unknown function (DUF3399)