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Mlp60A Muscle LIM protein at 60A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37853, updated on 2-Nov-2024

Summary

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Official Symbol
Mlp60Aprovided by FlyBase
Official Full Name
Muscle LIM protein at 60Aprovided by FlyBase
Primary source
FLYBASE:FBgn0259209
Locus tag
Dmel_CG42309
See related
AllianceGenome:FB:FBgn0259209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE14544; BcDNA:RH74176; CG30174; CG30179; CG3220; CG33149; CG42309; DLim-2; Dmel\CG42309; DmLIM-2; DMlp1; DMLP1; dMlp60A; FBgn0259209; MLIM 60A; MLP; Mlp1; MLP1; Mlp60; MLP60A
Old locus tag
Dmel_CG30174; Dmel_CG30179; Dmel_CG33149
Summary
Involved in muscle tissue development. Located in Z disc and nucleus. Colocalizes with actin cytoskeleton. Is expressed in several structures, including adult head; adult heart; larval muscle cell; larval muscle system; and somatic mesoderm. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Mlp60A in Genome Data Viewer
Location:
60B8-60B8; 2-106 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24074602..24078223)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19962125..19965746)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene yorkie Neighboring gene Glycerol-3-phosphate acyltransferase 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two muscle-specific LIM proteins in Drosophila. Stronach BE, et al. J Cell Biol, 1996 Sep. PMID 8794860, Free PMC Article
  2. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Arber S, et al. Cell, 1994 Oct 21. PMID 7954791
  3. Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ. Arber S, et al. Genes Dev, 1996 Feb 1. PMID 8595880
  4. The CRP/MLP/TLP family of LIM domain proteins: acting by connecting. Weiskirchen R, et al. Bioessays, 2003 Feb. PMID 12539241
  5. The Neuronal Overexpression of Gclc in Drosophila melanogaster Induces Life Extension With Longevity-Associated Transcriptomic Changes in the Thorax. Moskalev A, et al. Front Genet, 2019. PMID 30891062, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in muscle tissue development IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc HDA PubMed 
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
muscle LIM protein at 60A
Names
CG42309-PB
CG42309-PC
CG42309-PE
CG42309-PF
Mlp60A-PB
Mlp60A-PC
Mlp60A-PE
Mlp60A-PF
Muscle-specific LIM protein at 60A
muscle LIM protein 60A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24074602..24078223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299892.1 → NP_001286821.1  muscle LIM protein at 60A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286821.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP9
    Conserved Domains (3) summary
    cd09326
    Location:108 → 161
    LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
    cd09404
    Location:10 → 63
    LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    cl02475
    Location:316 → 369
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. NM_001144278.3 → NP_001137750.1  muscle LIM protein at 60A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137750.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZP9
    Conserved Domains (3) summary
    cd09326
    Location:108 → 161
    LIM_CRP_like; The LIM domains of Cysteine Rich Protein (CRP) family
    cd09404
    Location:10 → 63
    LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    cl02475
    Location:316 → 369
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_176255.3 → NP_788435.1  muscle LIM protein at 60A, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788435.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53777, Q1RKS4, Q9W1B4
    UniProtKB/TrEMBL
    A0A0B4LGF8
    Related
    FBpp0288974
    Conserved Domains (1) summary
    cd09404
    Location:10 → 63
    LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

  4. NM_001299891.1 → NP_001286820.1  muscle LIM protein at 60A, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53777, Q1RKS4, Q9W1B4
    UniProtKB/TrEMBL
    A0A0B4LGF8
    Conserved Domains (1) summary
    cd09404
    Location:10 → 63
    LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LGF8 A0A0B4LGF8
B7YZP9 B7YZP9
P53777.1 P53777

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