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EBNA-3B/EBNA-3C nuclear antigen EBNA-3B;nuclear antigen EBNA-3C [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783763, updated on 18-Aug-2023

Summary

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Gene symbol
EBNA-3B/EBNA-3C
Gene description
nuclear antigen EBNA-3B;nuclear antigen EBNA-3C
Locus tag
HHV4_EBNA-3B/EBNA-3C
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (11305..89482)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene membrane protein LMP-2B Neighboring gene membrane protein LMP-2A Neighboring gene tegument protein G75 Neighboring gene nuclear antigen EBNA-3A Neighboring gene interleukin-10 BCRF1 Neighboring gene nuclear antigen EBNA-2 Neighboring gene protein-coding Neighboring gene nuclear antigen EBNA-LP Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BWRF1 Neighboring gene protein BHLF1 Neighboring gene apoptosis regulator BHRF1 Neighboring gene nuclear egress lamina protein Neighboring gene DNA packaging protein UL32 Neighboring gene DNA packaging protein UL33 Neighboring gene nuclear egress membrane protein Neighboring gene protein UL49 Neighboring gene nuclear antigen EBNA-1 Neighboring gene small capsid protein Neighboring gene large tegument protein Neighboring gene tegument protein UL37 Neighboring gene multifunctional expression regulator Neighboring gene capsid triplex subunit 1 Neighboring gene ribonucleotide reductase subunit 1 Neighboring gene ribonucleotide reductase subunit 2 Neighboring gene DNA polymerase processivity subunit Neighboring gene envelope protein UL43 Neighboring gene helicase-primase primase subunit Neighboring gene tegument protein UL51 Neighboring gene deoxyuridine triphosphatase Neighboring gene envelope glycoprotein N Neighboring gene virion protein G52 Neighboring gene protein BLLF2 Neighboring gene glycoprotein 350 Neighboring gene envelope glycoprotein 42 Neighboring gene protein Zta Neighboring gene protein Rta Neighboring gene protein G49

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder. Maloney EM, et al. JCI Insight, 2020 Mar 26. PMID 32213705, Free PMC Article
  2. Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. Gain C, et al. PLoS Pathog, 2020 Feb. PMID 32092124, Free PMC Article
  3. An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model. Romero-Masters JC, et al. PLoS Pathog, 2018 Aug. PMID 30125329, Free PMC Article
  4. Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Bhattacharjee S, et al. Cell Death Dis, 2018 May 22. PMID 29789559, Free PMC Article
  5. The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells. Allday MJ, et al. Curr Top Microbiol Immunol, 2015. PMID 26428372

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder.
    Title: Genomic variations in EBNA3C of EBV associate with posttransplant lymphoproliferative disorder.
  2. the degradation signal is present at the first 50 residues of the N-terminal region of EBNA3C. Proteasomal inhibition reduces the colony formation ability of this important viral oncoprotein, induces apoptotic cell death and increases transcriptional activation of both latent and lytic gene expression which further promotes viral reactivation from EBV transformed B-lymphocytes.
    Title: Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.
  3. a new role of an essential EBV oncoprotein in regulating autophagy cascade as a survival mechanism, is reported.
    Title: Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival.
  4. EBNA3C contributes to, but is not essential for, EBV-induced lymphomagenesis in CBH mice, and suggest potentially important immunologic roles of EBNA3C in vivo.
    Title: An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.
  5. Our results provide novel insights into the function of EBNA3C on cell progression by regulating the cyclin D2 protein and raise the possibility of the development of new anticancer therapies against EBV-associated cancers.
    Title: Epstein-Barr Virus Nuclear Antigen 3C Facilitates Cell Proliferation by Regulating Cyclin D2.
  6. EBNA3B restrains the oncogenic capacity of EBV, so it acts as a tumour suppressor.[review]
    Title: The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells.
  7. EBNA3C is necessary to overcome an EBV-driven increase in p16(INK4a) expression and concomitant block to proliferation 2-4 weeks post-infection.
    Title: Induction of p16(INK4a) is the major barrier to proliferation when Epstein-Barr virus (EBV) transforms primary B cells into lymphoblastoid cell lines.
  8. The p73-mediated apoptotic pathway is inhibited in the presence of EBNA3C.
    Title: Epstein-Barr virus nuclear antigen 3C interact with p73: Interplay between a viral oncoprotein and cellular tumor suppressor.
  9. During latency, out of a subset of viral genes expressed, EBNA-3C is one of the essential antigens required for in vitro primary B-cell transformation.
    Title: Impact of EBV essential nuclear protein EBNA-3C on B-cell proliferation and apoptosis.
  10. This study provided formal proof that when EBV represses BIM transcription in B cells, expression of both EBNA3A and EBNA3C is necessary for the assembly of PRC2 on the BIM promoter and the deposition of the epigenetic repressive mark H3K27me3.
    Title: BIM promoter directly targeted by EBNA3C in polycomb-mediated repression by EBV.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: 11305-11310 regulatory_class = TATA_box
  • Loc: 14352-14357 regulatory_class = TATA_box
  • Loc: 17424-17429 regulatory_class = TATA_box
  • Loc: 20496-20501 regulatory_class = TATA_box
  • Loc: 23568-23573 regulatory_class = TATA_box
  • Loc: 26640-26645 regulatory_class = TATA_box
  • Loc: 29712-29717 regulatory_class = TATA_box
  • Loc: 32784-32789 regulatory_class = TATA_box
  • Loc: 37715-37720 regulatory_class = polyA_signal_sequence
  • Loc: 41471-41476 regulatory_class = TATA_box
  • Loc: 43230-43235 regulatory_class = polyA_signal_sequence
  • Loc: 46544-46549 regulatory_class = TATA_box
  • Loc: 49056-49061 regulatory_class = TATA_box
  • Loc: 49781-49786 regulatory_class = polyA_signal_sequence
  • Loc: 62729-62734 regulatory_class = TATA_box
  • Loc: 63881-63886 regulatory_class = TATA_box
  • Loc: 66516-66521 regulatory_class = TATA_box
  • Loc: 66595-66600 regulatory_class = polyA_signal_sequence
  • Loc: 67552-67557 regulatory_class = TATA_box
  • Loc: 68491-68496 regulatory_class = TATA_box
  • Loc: 68544-68549 regulatory_class = TATA_box
  • Loc: 69892-69897 regulatory_class = polyA_signal_sequence
  • Loc: 74594-74599 regulatory_class = TATA_box
  • Loc: 75311-75316 regulatory_class = polyA_signal_sequence
  • Loc: 76219-76224 regulatory_class = TATA_box
  • Loc: 76575-76580 regulatory_class = TATA_box
  • Loc: 77124-77129 regulatory_class = polyA_signal_sequence
  • Loc: 82933-82938 regulatory_class = polyA_signal_sequence
  • Loc: 89477-89482 regulatory_class = polyA_signal_sequence

rep_origin

  • Loc: 40301-41293

Repeated regions

  • Loc: 12001-15072 rpt_family = IR1; W , rpt_type = direct
  • Loc: 12001-35355 rpt_family = IR1; W , rpt_type = direct , rpt_unit_range = 12001..15072 (3072 bp)
  • Loc: 15073-18144 rpt_family = IR1; W , rpt_type = direct
  • Loc: 18145-21216 rpt_family = IR1; W , rpt_type = direct
  • Loc: 21217-24288 rpt_family = IR1; W , rpt_type = direct
  • Loc: 24289-27360 rpt_family = IR1; W , rpt_type = direct
  • Loc: 27361-30432 rpt_family = IR1; W , rpt_type = direct
  • Loc: 30433-33504 rpt_family = IR1; W , rpt_type = direct
  • Loc: 33505-35355 rpt_family = IR1; W , rpt_type = direct
  • Loc: 36390-36512 rpt_unit_range = 36390..36398
  • Loc: 37237-37290 rpt_unit_range = 37237..37242
  • Loc: 38290-39827 rpt_family = IR2; NotI , rpt_type = direct , rpt_unit_range = 38290..38414
  • Loc: 40366-41409 rpt_family = DR , rpt_type = direct
  • Loc: 57396-57642 rpt_unit_range = 57396..57446
  • Loc: 58099-58233 rpt_unit_range = 58099..58113
  • Loc: 70031-70173 rpt_unit_range = 70031..70101
  • Loc: 71352-71441 rpt_unit_range = 71352..71360
  • Loc: 77889-78351 rpt_unit_range = 77889..77919
  • Loc: 81920-81989 rpt_family = type A
  • Loc: 81993-82018 rpt_family = type B
  • Loc: 82019-82093 rpt_family = type C
  • Loc: 82098-82123 rpt_family = type B
  • Loc: 82124-82201 rpt_family = type C
  • Loc: 82202-82272 rpt_family = type A
  • Loc: 82283-82360 rpt_family = type C
  • Loc: 82361-82431 rpt_family = type A
  • Loc: 82608-82694 rpt_family = type D
  • Loc: 82695-82781 rpt_family = type D
  • Loc: 85234-85410 rpt_unit_range = 85234..85293
  • Loc: 87834-88016 rpt_unit_range = 87834..87848
  • Loc: 88377-88493 rpt_unit_range = 88377..88415

variation

  • Loc: 33127-40536
  • Loc: 33356-40162

General protein information

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Preferred Names
nuclear antigen EBNA-3B;nuclear antigen EBNA-3C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    11305..89482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401670.1 nuclear antigen EBNA-3B [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401670.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03203, Q777E8
    UniProtKB/TrEMBL
    A0A0B6VHN8, A0A0C7TXV9
    Conserved Domains (2) summary
    PHA03378
    Location:1 → 938
    PHA03378; EBNA-3B; Provisional
    pfam05009
    Location:145 → 404
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

  2. YP_401671.1 nuclear antigen EBNA-3C [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401671.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03204, Q777E7
    UniProtKB/TrEMBL
    A0A0B6VJ05, A0A120GXX6
Nucleotide Protein
Heading Accession and Version

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