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BZLF1 protein Zta [ Human gammaherpesvirus 4 (Epstein-Barr virus) ]

Gene ID: 3783744, updated on 18-Aug-2023

Summary

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Gene symbol
BZLF1
Gene description
protein Zta
Locus tag
HHV4_BZLF1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 4 (strain: B95-8, strain: Raji, type: 1, common: Epstein-Barr virus, acronym: EBV, acronym: HHV-4, nat-host: Homo sapiens)
Lineage
Viruses; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
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Genomic context

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Sequence:
NC_007605.1 (89838..90943, complement)

NC_007605.1Genomic Context describing neighboring genes Neighboring gene nuclear antigen EBNA-3B;nuclear antigen EBNA-3C Neighboring gene nuclear antigen EBNA-3A Neighboring gene protein-coding Neighboring gene nuclear antigen EBNA-1 Neighboring gene protein BLLF2 Neighboring gene glycoprotein 350 Neighboring gene envelope glycoprotein 42 Neighboring gene protein Rta Neighboring gene protein G49 Neighboring gene tegument protein G48

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007605.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocorticoids activate Epstein Barr virus lytic replication through the upregulation of immediate early BZLF1 gene expression. Yang EV, et al. Brain Behav Immun, 2010 Oct. PMID 20466055, Free PMC Article
  2. Epstein-Barr virus BZLF1 protein impairs accumulation of host DNA damage proteins at damage sites in response to DNA damage. Yang J, et al. Lab Invest, 2015 Aug. PMID 26006018
  3. Methylation-dependent binding of the epstein-barr virus BZLF1 protein to viral promoters. Dickerson SJ, et al. PLoS Pathog, 2009 Mar. PMID 19325883, Free PMC Article
  4. Quantitative evaluation of the role of Epstein-Barr virus immediate-early protein BZLF1 in B-cell transformation. Katsumura KR, et al. J Gen Virol, 2009 Oct. PMID 19553389
  5. [Characterization of BZLF1 gene and its promoter Zp of EBV strains in children with EBV-associated diseases in recent 5 years in Beijing area]. Liu YL, et al. Bing Du Xue Bao, 2014 Jan. PMID 24772891

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3'UTR and Regulates the Lytic Cycle.
    Title: Epstein-Barr Virus miR-BHRF1-3 Targets the BZLF1 3'UTR and Regulates the Lytic Cycle.
  2. The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.
    Title: The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.
  3. Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta.
    Title: Ubiquitin Modification of the Epstein-Barr Virus Immediate Early Transactivator Zta.
  4. A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents.
    Title: A Mechanism-Based Targeted Screen To Identify Epstein-Barr Virus-Directed Antiviral Agents.
  5. Reactivation of Epstein-Barr Virus by HIF-1alpha Requires p53.
    Title: Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.
  6. Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.
    Title: Nascent Transcriptomics Reveal Cellular Prolytic Factors Upregulated Upstream of the Latent-to-Lytic Switch Protein of Epstein-Barr Virus.
  7. Zta reduces the effectiveness of NFATc2, and that this is important to prevent cells from dying before viral replication is complete and the mature virus is released from the cells. This sequence-specific DNA-binding protein can disrupt EBV latency by driving the transcription of target genes and by interacting with the EBV lytic origin of replication.
    Title: Identifying the Cellular Interactome of Epstein-Barr Virus Lytic Regulator Zta Reveals Cellular Targets Contributing to Viral Replication.
  8. Results identify the EBV early lytic gene BGLF4-encoded viral protein kinase as a candidate that enhances expression of the viral latency-to-lytic switch protein ZEBRA. Activity of the BZLF1 promoter is determined by a balance of positive and negative transcription factors that epigenetically mediate activating and silencing marks on histones.
    Title: Retrograde Regulation by the Viral Protein Kinase Epigenetically Sustains the Epstein-Barr Virus Latency-to-Lytic Switch To Augment Virus Production.
  9. Noncanonical Basic Motif of Epstein-Barr Virus ZEBRA Protein Facilitates Recognition of Methylated DNA, High-Affinity DNA Binding, and Lytic Activation.
    Title: A Noncanonical Basic Motif of Epstein-Barr Virus ZEBRA Protein Facilitates Recognition of Methylated DNA, High-Affinity DNA Binding, and Lytic Activation.
  10. These BZLF1 transcripts consisted of not only the normally spliced variant but also a completely unspliced and a spliced variant containing exons one and three only. In contrast, we detected only the normally spliced version of the BZLF1 transcript in B-cell lines
    Title: BZLF1 transcript variants in Epstein-Barr virus-positive epithelial cell lines.
Submit: New GeneRIF Correction See all GeneRIFs (78)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c89868-89863 regulatory_class = polyA_signal_sequence
  • Loc: c89872-89867 regulatory_class = TATA_box
  • Loc: c90943-90938 regulatory_class = TATA_box

General protein information

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Preferred Names
protein Zta

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007605.1 Reference assembly

    Range
    89838..90943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_401673.1 protein Zta [Human gammaherpesvirus 4]

    See identical proteins and their annotated locations for YP_401673.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P03206, Q69127, Q777E5
    UniProtKB/TrEMBL
    A0A060A1C8, A0A060A1R5, A0A060A629, A0A0C7TIV5, A0A0C7TP04, K9URC5
    Conserved Domains (1) summary
    cd14809
    Location:175 → 226
    bZIP_AUREO-like; Basic leucine zipper (bZIP) domain of blue light (BL) receptor aureochrome (AUREO) and similar bZIP domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
1512292A.1

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