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thoc5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37810, updated on 10-May-2024

Summary

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Official Symbol
thoc5provided by FlyBase
Primary source
FLYBASE:FBgn0034939
Locus tag
Dmel_CG2980
See related
AllianceGenome:FB:FBgn0034939
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2980; Dmel\CG2980; garm; Thoc5; THOC5
Summary
Predicted to enable mRNA binding activity. Involved in male meiotic nuclear division. Located in nucleus. Part of THO complex. Colocalizes with nuclear chromosome and nucleolus. Is expressed in organism. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See thoc5 in Genome Data Viewer
Location:
60A13-60A13; 2-105 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23954091..23956406)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19841614..19843929)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Stomatin like 2 Neighboring gene fizzy-related 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha-catenin related Neighboring gene uncharacterized protein Neighboring gene Flavin-containing monooxygenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. p53 and PI3K/AKT signalings are up-regulated in flies with defects in the THO complex. Moon S, et al. Mol Cells, 2013 Mar. PMID 23475424, Free PMC Article
  2. piRNA-independent transposon silencing by the Drosophila THO complex. Zhang G, et al. Dev Cell, 2021 Sep 27. PMID 34547226, Free PMC Article
  3. Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin. Zhang G, et al. Cell Rep, 2018 Sep 25. PMID 30257203, Free PMC Article
  4. [Interactions of the TREX-2 complex with mRNP particle of β-tubulin 56D gene]. Popova VV, et al. Mol Biol (Mosk), 2016 Nov-Dec. PMID 28064320
  5. Zinc Finger Protein CG9890 - New Component of ENY2-Containing Complexes of Drosophila. Fursova NA, et al. Acta Naturae, 2018 Oct-Dec. PMID 30713769, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Flies lacking THOC5 showed a meiotic arrest phenotype with severe nucleolar disruption in primary spermatocytes.
    Title: The THO complex is required for nucleolar integrity in Drosophila spermatocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribonucleoprotein complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus in response to heat stress IC
Inferred by Curator
more info
 PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription export complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
thoc5
Names
CG2980-PA
garmcho
thoc5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23954091..23956406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138012.3 → NP_611856.1  thoc5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611856.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95RL0, Q9W1F4
    Related
    FBpp0072056
    Conserved Domains (1) summary
    pfam09766
    Location:48 → 392
    FimP; Fms-interacting protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W1F4.2 Q9W1F4

Gene LinkOut

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