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Nap1 Nucleosome assembly protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37798, updated on 2-Nov-2024

Summary

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Official Symbol
Nap1provided by FlyBase
Official Full Name
Nucleosome assembly protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0015268
Locus tag
Dmel_CG5330
See related
AllianceGenome:FB:FBgn0015268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5330; dCAF-4; Dmel\CG5330; dNAP-1; dNap1; dNAP1; nap-1; Nap-1; NAP-1; nap1; NAP1; p56; p56/dCAF-4
Summary
Enables histone binding activity. Involved in several processes, including DNA replication-dependent chromatin assembly; nucleosome assembly; and nucleus organization. Located in mitochondrion and nucleus. Is expressed in several structures, including embryonic/larval midgut primordium; ganglia; gland; larval muscle cell; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to several human genes including NAP1L1 (nucleosome assembly protein 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nap1 in Genome Data Viewer
Location:
60A9-60A9; 2-105 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23905175..23907294, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19792698..19794817, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lost PHDs of trr Neighboring gene antisense RNA:CR45926 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44806 Neighboring gene kazachoc Neighboring gene uncharacterized protein Neighboring gene Sarco/endoplasmic reticulum Ca(2+)-ATPase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter. Sharma N, et al. Proc Natl Acad Sci U S A, 2008 Jun 10. PMID 18523016, Free PMC Article
  2. Nucleosome assembly dynamics involve spontaneous fluctuations in the handedness of tetrasomes. Vlijm R, et al. Cell Rep, 2015 Jan 13. PMID 25578730
  3. Histone chaperone-mediated co-expression assembly of tetrasomes and nucleosomes. Okimune KI, et al. FEBS Open Bio, 2021 Nov. PMID 34614293, Free PMC Article
  4. The high-affinity Sp1 binding site in the HTLV-1 promoter contributes to Tax-independent basal expression. Livengood JA, et al. Nucleic Acids Res, 2004. PMID 15155851, Free PMC Article
  5. Knockout targeting of the Drosophila nap1 gene and examination of DNA repair tracts in the recombination products. Lankenau S, et al. Genetics, 2003 Feb. PMID 12618400, Free PMC Article

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nucleosome assembly protein 1 is a regulator of histone H1 acetylation.
    Title: Nucleosome assembly protein 1 is a regulator of histone H1 acetylation.
  2. show that NAP-1 regulates the transcription of the HeT-A retrotransposon, pointing to a positive regulatory role of NAP-1 in telomere expression
    Title: NAP-1, Nucleosome assembly protein 1, a histone chaperone involved in Drosophila telomeres.
  3. We find that the assembly of H3.3-containing tetrasomes and nucleosomes by the histone chaperone Nucleosome Assembly Protein 1 (NAP1) occurs in an identical manner to that of H3-containing tetrasomes and nucleosomes.
    Title: Comparing the Assembly and Handedness Dynamics of (H3.3-H4)2 Tetrasomes to Canonical Tetrasomes.
  4. We conclude that the balanced antagonism between NAP1 and PP2A controls cohesin dissociation during mitosis
    Title: Histone chaperone NAP1 mediates sister chromatid resolution by counteracting protein phosphatase 2A.
  5. Data indicate the essential roles of two Nap family proteins, CG5017/Hanabi and nucleosome assembly protein 1 (Nap1) in spermatogenesis.
    Title: The Nap family proteins, CG5017/Hanabi and Nap1, are essential for Drosophila spermiogenesis.
  6. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
    Title: The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.
  7. Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.
    Title: Histone chaperones ASF1 and NAP1 differentially modulate removal of active histone marks by LID-RPD3 complexes during NOTCH silencing.
  8. These findings reveal a unique mechanism in which the DNA-bound Tax/pCREB complex recruits CBP/p300, and together with NAP1, the coactivators cooperate to dramatically reduce nucleosome occupancy at the viral promoter.
    Title: The coactivators CBP/p300 and the histone chaperone NAP1 promote transcription-independent nucleosome eviction at the HTLV-1 promoter.
  9. Nap-1 functions to help to assemble chromatin into a closed form, as does HP2
    Title: Heterochromatin protein 2 interacts with Nap-1 and NURF: a link between heterochromatin-induced gene silencing and the chromatin remodeling machinery in Drosophila.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication-dependent chromatin assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm DNA decondensation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
nucleosome assembly protein 1
Names
CG5330-PA
CG5330-PB
CG5330-PC
Nap1-PA
Nap1-PB
Nap1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23905175..23907294 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057780.4 → NP_477128.1  nucleosome assembly protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477128.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24150, Q9W1G7
    Related
    FBpp0072128
    Conserved Domains (1) summary
    pfam00956
    Location:55 → 321
    NAP; Nucleosome assembly protein (NAP)

  2. NM_001259556.1 → NP_001246485.1  nucleosome assembly protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246485.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24150, Q9W1G7
    Conserved Domains (1) summary
    pfam00956
    Location:55 → 321
    NAP; Nucleosome assembly protein (NAP)

  3. NM_001259557.2 → NP_001246486.1  nucleosome assembly protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246486.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24150, Q9W1G7
    Conserved Domains (1) summary
    pfam00956
    Location:55 → 321
    NAP; Nucleosome assembly protein (NAP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24150 Q24150
Q9W1G7 Q9W1G7

Gene LinkOut

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