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Sgf29 SAGA-associated factor 29kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37429, updated on 10-May-2024

Summary

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Official Symbol
Sgf29provided by FlyBase
Official Full Name
SAGA-associated factor 29kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0050390
Locus tag
Dmel_CG30390
See related
AllianceGenome:FB:FBgn0050390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10509; CG30390; Dmel\CG30390; dSgf29; sgf29
Summary
Predicted to enable methylated histone binding activity. Involved in chromatin remodeling and histone H3 acetylation. Located in nucleus. Part of ATAC complex; H3 histone acetyltransferase complex; and SAGA complex. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human SGF29 (SAGA complex associated factor 29). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Sgf29 in Genome Data Viewer
Location:
57D8-57D8; 2-94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21292239..21293646, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17179744..17181151, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Major Facilitator Superfamily Transporter 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L29 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44724 Neighboring gene Ankyrin repeat-rich membrane spanning

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a metazoan ADA acetyltransferase complex. Soffers JHM, et al. Nucleic Acids Res, 2019 Apr 23. PMID 30715476, Free PMC Article
  2. Chiffon triggers global histone H3 acetylation and expression of developmental genes in Drosophila embryos. Torres-Zelada EF, et al. J Cell Sci, 2022 Jan 15. PMID 34908116, Free PMC Article
  3. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. Torres-Zelada EF, et al. J Cell Sci, 2019 Jan 16. PMID 30559249, Free PMC Article
  4. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
  5. Proteomic analysis of Drosophila CLOCK complexes identifies rhythmic interactions with SAGA and Tip60 complex component NIPPED-A. Mahesh G, et al. Sci Rep, 2020 Oct 21. PMID 33087840, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of H3 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
SAGA-associated factor 29kDa
Names
CG30390-PA
CG30390-PB
SAGA-associated factor 29 ortholog
Sgf29-PA
Sgf29-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21292239..21293646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299744.1 → NP_001286673.1  SAGA-associated factor 29kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286673.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2I4
    Conserved Domains (1) summary
    pfam07039
    Location:143 → 273
    DUF1325; SGF29 tudor-like domain

  2. NM_166436.3 → NP_726051.1  SAGA-associated factor 29kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W2I4
    Related
    FBpp0071543
    Conserved Domains (1) summary
    pfam07039
    Location:143 → 273
    DUF1325; SGF29 tudor-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2I4 Q9W2I4

Gene LinkOut

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