WNT2B Wnt family member 2B [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: WNT2Bprovided by CGNC
Official Full Name: Wnt family member 2Bprovided by CGNC
Primary source: CGNC:49099
See related: Ensembl:ENSGALG00010027417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 26

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	26	NC_052557.1 (3534457..3547126)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	26	NC_052598.1 (3502735..3515411)

Chromosome 26 - NC_052557.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeted inactivation of the TSK gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b and Fzd4 expression in the developing peripheral eye
Title: Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4.
Neural crest-derived TGFbs activate both Smad3 and Wnt2b signalling in the adjacent ectoderm to position the lens next to the retina.
Title: Neural crest cells organize the eye via TGF-β and canonical Wnt signalling.
The anterior optic cup domain, as described in part by Wnt2b expression, is specified through the elaboration of a border within the optic neuroepithelium rather than through interactions with the surrounding environment.
Title: The expression of Wnt2b in the optic cup lip requires a border between the pigmented and nonpigmented epithelium.
Wnt2b expression in the anterior rim of the developing retina is responsible for laminar structure of the retina layer.
Title: Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro.
WNT2B regulates embryonic forelimb development via FGF signaling and WNT/b-catenin signaling
Title: WNT signals control FGF-dependent limb initiation and AER induction in the chick embryo.
Wnt2b maintains the naive state of marginal progenitor cells by attenuating the expression of both proneural and neurogenic genes
Title: Wnt2b inhibits differentiation of retinal progenitor cells in the absence of Notch activity by downregulating the expression of proneural genes.
The expression of Wnt2b or constitutively active beta-catenin inhibited retinal progenitor gene (RPG) expression and the differentiation of retinal neurons.
Title: Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables frizzled binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein Wnt-2b

Names: wingless-type MMTV integration site family, member 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204336.4 → NP_989667.3 protein Wnt-2b precursor

Status: VALIDATED

Source sequence(s)

AF182403, AF346628, BX935899, JAENSK010000356

UniProtKB/Swiss-Prot

Q98SN7, Q9PUI3

Related

ENSGALP00010040732.1, ENSGALT00010066481.1

Conserved Domains (1) summary

cd19346
Location:61 → 374

Wnt_Wnt2b; Wnt domain found in protein Wnt-2b and similar proteins