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POU1F1 POU class 1 homeobox 1 [ Gallus gallus (chicken) ]

Gene ID: 374215, updated on 17-Aug-2024

Summary

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Official Symbol
POU1F1provided by CGNC
Official Full Name
POU class 1 homeobox 1provided by CGNC
Primary source
CGNC:11552
See related
Ensembl:ENSGALG00010007661
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PIT1; GHF-1; PIT-1; Pit-1*
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (93020689..93036563)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (93058808..93074681)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene cell surface glycoprotein CD200 receptor 1-A-like Neighboring gene 5-hydroxytryptamine receptor 1F Neighboring gene uncharacterized LOC121109439 Neighboring gene charged multivesicular body protein 2B Neighboring gene vestigial like family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphisms of Pit-1 gene and its association with growth traits in chicken. Bhattacharya TK, et al. Poult Sci, 2012 May. PMID 22499861
  2. The PIT1 gene polymorphisms were associated with chicken growth traits. Nie Q, et al. BMC Genet, 2008 Feb 27. PMID 18304318, Free PMC Article
  3. Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary. Van As P, et al. Acta Vet Hung, 2004. PMID 15595273
  4. A new single nucleotide polymorphism in the chicken pituitary-specific transcription factor (POU1F1) gene associated with growth rate. Jiang R, et al. Anim Genet, 2004 Aug. PMID 15265078
  5. Immunocytochemical identification of Pit-1 containing cells in the anterior pituitary of hens. Chowdhury VS, et al. J Reprod Dev, 2003 Oct. PMID 14967913

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of differential abilities of chicken Pit1 isoforms to regulate the GH promoter
    Title: Differential abilities of chicken Pit1 isoforms to regulate the GH promoter: evidence for synergistic activation.
  2. The Pit-1 gene is polymorphic and has a significant effect on growth traits in chickens.
    Title: Polymorphisms of Pit-1 gene and its association with growth traits in chicken.
  3. Data preliminarily deduced that MC4R and POU1F1 gene were probably the major gene on growth performance or a QTL linked gene which associated with growth performance in chicken.
    Title: [Genetic effects of MC4R and POU1F1 gene on the growth performance in Jinghai yellow chicken].
  4. Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits
    Title: The PIT1 gene polymorphisms were associated with chicken growth traits.
  5. Pit-1 has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH.
    Title: Regulation of growth hormone expression by thyrotropin-releasing hormone through the pituitary-specific transcription factor Pit-1 in chicken pituitary.
  6. Pit-1 protein induction occurs in 6 types of glandular cells, suggesting that Pit-1 may regulate hormone synthesis in each glandular cell in the anterior pituitary.
    Title: Immunocytochemical identification of Pit-1 containing cells in the anterior pituitary of hens.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pituitary-specific positive transcription factor 1
Names
POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
Pit-1/GHF-1
growth hormone factor 1
pituitary specific transcription factor
pituitary specific transcription factor-1
pituitary-specific positive transcription factor 1 variant alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396102.1 → NP_001383031.1  pituitary-specific positive transcription factor 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000019
    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8
    UniProtKB/TrEMBL
    A0A1D5NY46
    Related
    ENSGALP00010010024.1, ENSGALT00010018244.1
    Conserved Domains (2) summary
    smart00352
    Location:195 → 269
    POU; Found in Pit-Oct-Unc transcription factors
    smart00389
    Location:285 → 341
    HOX; Homeodomain

  2. NM_001396103.1 → NP_001383032.1  pituitary-specific positive transcription factor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000019
    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8
    Conserved Domains (2) summary
    smart00352
    Location:167 → 241
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:260 → 314
    Homeobox; Homeobox domain

  3. NM_204319.2 → NP_989650.1  pituitary-specific positive transcription factor 1 isoform 3

    See identical proteins and their annotated locations for NP_989650.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000019
    UniProtKB/TrEMBL
    F1NRJ0, H6U644, O57599
    Conserved Domains (2) summary
    smart00352
    Location:159 → 233
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:252 → 305
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    93020689..93036563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015295651.3 → XP_015151137.1  pituitary-specific positive transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8
    Conserved Domains (2) summary
    smart00352
    Location:202 → 276
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:295 → 348
    Homeobox; Homeobox domain

  2. XM_015295656.3 → XP_015151142.1  pituitary-specific positive transcription factor 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8
    Conserved Domains (2) summary
    smart00352
    Location:174 → 248
    POU; Found in Pit-Oct-Unc transcription factors
    pfam00046
    Location:267 → 320
    Homeobox; Homeobox domain

  3. XM_046943757.1 → XP_046799713.1  pituitary-specific positive transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    H6U644

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    93058808..93074681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906421.1 → XP_046762377.1  pituitary-specific positive transcription factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8

  2. XM_046906422.1 → XP_046762378.1  pituitary-specific positive transcription factor 1 isoform X2

    UniProtKB/Swiss-Prot
    Q9YGL7, Q9YGL8

  3. XM_046906423.1 → XP_046762379.1  pituitary-specific positive transcription factor 1 isoform X3

    UniProtKB/TrEMBL
    H6U644
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9YGL7.1 GenPept UniProtKB/Swiss-Prot:Q9YGL7

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