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PDCD4 programmed cell death 4 [ Gallus gallus (chicken) ]

Gene ID: 374191, updated on 10-Oct-2024

Summary

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Official Symbol
PDCD4provided by CGNC
Official Full Name
programmed cell death 4provided by CGNC
Primary source
CGNC:6604
See related
Ensembl:ENSGALG00010018265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PDCD4 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (26928005..26945127)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (26819017..26836149)

Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene uncharacterized LOC121111207 Neighboring gene uncharacterized LOC107053740 Neighboring gene uncharacterized LOC124418399 Neighboring gene uncharacterized LOC423893 Neighboring gene BBSome interacting protein 1 Neighboring gene SHOC2, leucine rich repeat scaffold protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation. Biyanee A, et al. Oncogene, 2015 Mar 12. PMID 24681950
  2. Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response. Singh P, et al. Oncogene, 2009 Oct 22. PMID 19684621
  3. Identification of the myb-inducible promoter of the chicken Pdcd4 gene. Schlichter U, et al. Biochim Biophys Acta, 2001 Jul 30. PMID 11470166
  4. The chicken Pdcd4 gene is regulated by v-Myb. Schlichter U, et al. Oncogene, 2001 Jan 11. PMID 11313950
  5. Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation. Singh P, et al. Oncogene, 2011 Dec 8. PMID 21643008

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This work reveals a novel mechanism by which Pdcd4 affects the translation of cellular RNAs.
    Title: A novel mechanism for the control of translation of specific mRNAs by tumor suppressor protein Pdcd4: inhibition of translation elongation.
  2. c-myb mRNA as the first natural translational target mRNA of Pdcd4
    Title: Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.
  3. Pdcd4 has an important function in the cellular response to DNA damage
    Title: Disruption of the Pdcd4 tumor suppressor gene in chicken DT40 cells reveals its role in the DNA-damage response.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
programmed cell death protein 4
Names
programmed cell death 4 (neoplastic transformation inhibitor)
protein I11/6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398101.1 → NP_001385030.1  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Related
    ENSGALP00010026221.1, ENSGALT00010044106.1
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  2. NM_001398102.1 → NP_001385031.1  programmed cell death protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    Conserved Domains (1) summary
    smart00544
    Location:324 → 437
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  3. NM_001398103.1 → NP_001385032.1  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  4. NM_001398104.1 → NP_001385033.1  programmed cell death protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    Conserved Domains (1) summary
    smart00544
    Location:324 → 437
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  5. NM_001398105.1 → NP_001385034.1  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  6. NM_001398106.1 → NP_001385035.1  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  7. NM_001398107.1 → NP_001385036.1  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  8. NM_001398108.1 → NP_001385037.1  programmed cell death protein 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    Conserved Domains (1) summary
    smart00544
    Location:324 → 437
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  9. NM_204304.2 → NP_989635.2  programmed cell death protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000232
    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Related
    ENSGALP00010026229.1, ENSGALT00010044116.1
    Conserved Domains (1) summary
    smart00544
    Location:325 → 438
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    26928005..26945127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046942693.1 → XP_046798649.1  programmed cell death protein 4 isoform X2

  2. XM_046942694.1 → XP_046798650.1  programmed cell death protein 4 isoform X2

  3. XM_040702216.2 → XP_040558150.1  programmed cell death protein 4 isoform X2

    UniProtKB/Swiss-Prot
    Q98TX3
    Conserved Domains (1) summary
    smart00544
    Location:324 → 437
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

  4. XM_046942690.1 → XP_046798646.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  5. XM_046942691.1 → XP_046798647.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  6. XM_046942692.1 → XP_046798648.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  7. XM_046942689.1 → XP_046798645.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
    Related
    ENSGALP00010026215.1, ENSGALT00010044097.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    26819017..26836149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046919789.1 → XP_046775745.1  programmed cell death protein 4 isoform X2

  2. XM_046919787.1 → XP_046775743.1  programmed cell death protein 4 isoform X2

  3. XM_046919788.1 → XP_046775744.1  programmed cell death protein 4 isoform X2

  4. XM_046919784.1 → XP_046775740.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  5. XM_046919785.1 → XP_046775741.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  6. XM_046919786.1 → XP_046775742.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3

  7. XM_046919783.1 → XP_046775739.1  programmed cell death protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A1D5PJQ4, A0A1L1RNB9, A0A1L1RXZ3, F1NIY3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q98TX3.1 GenPept UniProtKB/Swiss-Prot:Q98TX3

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