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PDGFB platelet derived growth factor subunit B [ Gallus gallus (chicken) ]

Gene ID: 374128, updated on 17-Aug-2024

Summary

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Symbol
PDGFBprovided by CGNC
Full Name
platelet derived growth factor subunit Bprovided by CGNC
Primary source
CGNC:9243
See related
Ensembl:ENSGALG00010012624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PDGFB in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (50759346..50777366)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (51056836..51075672)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109332 Neighboring gene small nucleolar RNA, C/D box 83A Neighboring gene ribosomal protein L3 Neighboring gene chromobox homolog 7 Neighboring gene chromobox 6 Neighboring gene neuronal pentraxin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a chicken platelet-derived growth factor B-chain cDNA. Horiuchi H, et al. Dev Comp Immunol, 2002 Jan. PMID 11687265
  2. Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period. Chen CH, et al. J Hand Surg Am, 2008 Dec. PMID 19084187
  3. Involvement of vessels and PDGFB in muscle splitting during chick limb development. Tozer S, et al. Development, 2007 Jul. PMID 17553906
  4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. platelet-derived growth factor B (PDGF-B) gene was also minimally expressed in healing tendon
    Title: Tendon healing in vivo: gene expression and production of multiple growth factors in early tendon healing period.
  2. PDGFB promotes the production of extracellular matrix and attracts connective tissue cells to the future splitting site, allowing separation of the muscle masses during the splitting process.
    Title: Involvement of vessels and PDGFB in muscle splitting during chick limb development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables platelet-derived growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in platelet-derived growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
platelet-derived growth factor subunit B
Names
platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204270.5 → NP_989601.3  platelet-derived growth factor subunit B precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    Q90W23
    Conserved Domains (2) summary
    pfam00341
    Location:104 → 187
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:30 → 100
    PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    50759346..50777366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015284373.4 → XP_015139859.3  platelet-derived growth factor subunit B isoform X1

    UniProtKB/TrEMBL
    Q90W23
    Conserved Domains (2) summary
    pfam00341
    Location:104 → 187
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:30 → 100
    PDGF_N; Platelet-derived growth factor, N terminal region

  2. XM_046942932.1 → XP_046798888.1  platelet-derived growth factor subunit B isoform X1

    UniProtKB/TrEMBL
    Q90W23

  3. XM_015284377.4 → XP_015139863.3  platelet-derived growth factor subunit B isoform X1

    UniProtKB/TrEMBL
    Q90W23
    Related
    ENSGALP00010017544.1, ENSGALT00010030230.1
    Conserved Domains (2) summary
    pfam00341
    Location:104 → 187
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:30 → 100
    PDGF_N; Platelet-derived growth factor, N terminal region

  4. XM_046942957.1 → XP_046798913.1  platelet-derived growth factor subunit B isoform X1

    UniProtKB/TrEMBL
    Q90W23

  5. XM_015284369.4 → XP_015139855.3  platelet-derived growth factor subunit B isoform X1

    UniProtKB/TrEMBL
    Q90W23
    Conserved Domains (2) summary
    pfam00341
    Location:104 → 187
    PDGF; PDGF/VEGF domain
    pfam04692
    Location:30 → 100
    PDGF_N; Platelet-derived growth factor, N terminal region

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    51056836..51075672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906403.1 → XP_046762359.1  platelet-derived growth factor subunit B isoform X1

  2. XM_046906404.1 → XP_046762360.1  platelet-derived growth factor subunit B isoform X1

  3. XM_046906402.1 → XP_046762358.1  platelet-derived growth factor subunit B isoform X1

  4. XM_046906405.1 → XP_046762361.1  platelet-derived growth factor subunit B isoform X1

  5. XM_046906401.1 → XP_046762357.1  platelet-derived growth factor subunit B isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials