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LITAF lipopolysaccharide induced TNF factor [ Gallus gallus (chicken) ]

Gene ID: 374125, updated on 10-Oct-2024

Summary

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Symbol
LITAFprovided by CGNC
Full Name
lipopolysaccharide induced TNF factorprovided by CGNC
Primary source
CGNC:2338
See related
Ensembl:ENSGALG00010021744
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TNF-alpha
Orthologs
human mouse all
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Genomic context

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See LITAF in Genome Data Viewer
Location:
chromosome: 14
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (925629..945258)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (924136..943851)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene thioredoxin domain containing 11 Neighboring gene stannin Neighboring gene uncharacterized LOC101751635 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds. Rohde F, et al. Front Immunol, 2018. PMID 29719531, Free PMC Article
  2. Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract. Gao X, et al. Biol Trace Elem Res, 2016 Sep. PMID 26899319
  3. Molecular cloning and characterization of chicken lipopolysaccharide-induced TNF-alpha factor (LITAF). Hong YH, et al. Dev Comp Immunol, 2006. PMID 16466659
  4. Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination. Das SC, et al. Reproduction, 2009 Mar. PMID 18539728
  5. The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. Sevimli A, et al. Vet Res Commun, 2008 Oct. PMID 18612836

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this paper provides characterization of chicken tumor necrosis factor-alpha
    Title: Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds.
  2. The results showed that Se deficiency induced high expression levels of PTGE, COX-2, TNF-alpha, and NF-kappaB in the gastrointestinal tract tissues.
    Title: Selenium Deficiency-Induced Inflammation and Increased Expression of Regulating Inflammatory Cytokines in the Chicken Gastrointestinal Tract.
  3. The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment.
    Title: Arsenic Trioxide Attenuates NF-κB and Cytokine mRNA Levels in the Livers of Cocks.
  4. Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age.
    Title: Changes of IgA+ cells and cytokines in the cecal tonsil of broilers fed on diets supplemented with vanadium.
  5. IL1B and LITAF mRNAs are increased in the vagina during insemination. This response may lead to sperm degradation and elimination.
    Title: Changes in the expression of interleukin-1beta and lipopolysaccharide-induced TNF factor in the oviduct of laying hens in response to artificial insemination.
  6. The expression of interleukin(IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in amyoidosis arthropathy in chickens was studied.
    Title: The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
Names
LPS-induced TNF-alpha factor homolog
TNF-alpha factor
lipid-induced TNF-alpha factor
small integral membrane protein of lysosome/late endosome
tissue necrosis factor-alpha
tumor necrosis factor-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204267.2 → NP_989598.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

    See identical proteins and their annotated locations for NP_989598.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000257
    UniProtKB/Swiss-Prot
    Q8QGW7
    UniProtKB/TrEMBL
    A0A8V0ZLT0
    Related
    ENSGALP00010031766.1, ENSGALT00010052860.1
    Conserved Domains (1) summary
    pfam10601
    Location:78 → 146
    zf-LITAF-like; LITAF-like zinc ribbon domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    925629..945258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046900549.1 → XP_046756505.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

  2. XM_046900551.1 → XP_046756507.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7
    Related
    ENSGALP00010031765.1, ENSGALT00010052859.1

  3. XM_015294124.4 → XP_015149610.2  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7
    UniProtKB/TrEMBL
    A0A8V0ZLT0
    Conserved Domains (1) summary
    pfam10601
    Location:78 → 146
    zf-LITAF-like; LITAF-like zinc ribbon domain

  4. XM_040647304.2 → XP_040503238.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7
    UniProtKB/TrEMBL
    A0A8V0ZLT0
    Conserved Domains (1) summary
    pfam10601
    Location:78 → 146
    zf-LITAF-like; LITAF-like zinc ribbon domain

  5. XM_015294121.4 → XP_015149607.2  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7
    UniProtKB/TrEMBL
    A0A8V0ZLT0
    Conserved Domains (1) summary
    pfam10601
    Location:78 → 146
    zf-LITAF-like; LITAF-like zinc ribbon domain

  6. XM_046900550.1 → XP_046756506.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    924136..943851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927262.1 → XP_046783218.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

  2. XM_046927263.1 → XP_046783219.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

  3. XM_046927265.1 → XP_046783221.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

  4. XM_046927261.1 → XP_046783217.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7

  5. XM_046927264.1 → XP_046783220.1  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog isoform X1

    UniProtKB/Swiss-Prot
    Q8QGW7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QGW7.1 GenPept UniProtKB/Swiss-Prot:Q8QGW7

Gene LinkOut

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Molecular Biology Databases
Research Materials