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CALD1 caldesmon 1 [ Gallus gallus (chicken) ]

Gene ID: 373965, updated on 17-Aug-2024

Summary

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Official Symbol
CALD1provided by CGNC
Official Full Name
caldesmon 1provided by CGNC
Primary source
CGNC:9884
See related
Ensembl:ENSGALG00010013465
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See CALD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (62331101..62515527)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (62638929..62822881)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053343 Neighboring gene bisphosphoglycerate mutase Neighboring gene uncharacterized LOC121107601 Neighboring gene aldo-keto reductase family 1 member B10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity. Hamden SS, et al. Biophys J, 2010 Sep 22. PMID 20858431, Free PMC Article
  2. Modulation of actin mechanics by caldesmon and tropomyosin. Greenberg MJ, et al. Cell Motil Cytoskeleton, 2008 Feb. PMID 18000881, Free PMC Article
  3. Visualization of caldesmon binding to synthetic filaments of smooth muscle myosin. Kulikova N, et al. J Muscle Res Cell Motil, 2003. PMID 12953833
  4. Common structural and expressional properties of vertebrate caldesmon genes. Haruna M, et al. Biochem Biophys Res Commun, 1993 Nov 30. PMID 8250919
  5. Calcium-dependent regulation of the caldesmon-heavy meromyosin interaction by caltropin. Mani RS, et al. Biochemistry, 1993 Oct 19. PMID 8218186

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the region between residues 627 and 642 may contribute to the overall regulation of caldesmon's activity
    Title: Phosphorylation of caldesmon at sites between residues 627 and 642 attenuates inhibitory activity and contributes to a reduction in Ca2+-calmodulin affinity.
  2. interstrand crosslinking by the C-terminal actin-binding fragment of caldesmon, H32K, increases persistence length by 1.6-fold for actin filament
    Title: Modulation of actin mechanics by caldesmon and tropomyosin.
  3. steady state actomyosin ATPase by caldesmon and tropomyosin
    Title: The mechanism of smooth muscle caldesmon-tropomyosin inhibition of the elementary steps of the actomyosin ATPase.
  4. unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells
    Title: Modes of caldesmon binding to actin: sites of caldesmon contact and modulation of interactions by phosphorylation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables myosin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
caldesmon
Names
CDM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396084.1 → NP_001383013.1  caldesmon isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A1L1RKY9
    Related
    ENSGALP00010019203.1, ENSGALT00010032450.1
    Conserved Domains (1) summary
    PTZ00121
    Location:21 → 344
    PTZ00121; MAEBL; Provisional

  2. NM_001396085.1 → NP_001383014.1  caldesmon isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A8V0YSR1
    Related
    ENSGALP00010019225.1, ENSGALT00010032478.1

  3. NM_001396086.1 → NP_001383015.1  caldesmon isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Conserved Domains (1) summary
    PTZ00121
    Location:21 → 344
    PTZ00121; MAEBL; Provisional

  4. NM_001396087.1 → NP_001383016.1  caldesmon isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    Conserved Domains (1) summary
    PTZ00121
    Location:21 → 344
    PTZ00121; MAEBL; Provisional

  5. NM_001396088.1 → NP_001383017.1  caldesmon isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012
    UniProtKB/TrEMBL
    A0A1L1RKY9
    Conserved Domains (1) summary
    PTZ00121
    Location:21 → 344
    PTZ00121; MAEBL; Provisional

  6. NM_204158.2 → NP_989489.2  caldesmon isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000012

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    62331101..62515527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939671.1 → XP_046795627.1  caldesmon isoform X3

    UniProtKB/TrEMBL
    A0A8V0YSR1

  2. XM_046939721.1 → XP_046795677.1  caldesmon isoform X4

  3. XM_046939810.1 → XP_046795766.1  caldesmon isoform X8

  4. XM_046939851.1 → XP_046795807.1  caldesmon isoform X9

    UniProtKB/TrEMBL
    A0A1L1RKY9

  5. XM_046939748.1 → XP_046795704.1  caldesmon isoform X4

  6. XM_046939814.1 → XP_046795770.1  caldesmon isoform X8

  7. XM_046939906.1 → XP_046795862.1  caldesmon isoform X9

    UniProtKB/TrEMBL
    A0A1L1RKY9

  8. XM_046939684.1 → XP_046795640.1  caldesmon isoform X3

    UniProtKB/TrEMBL
    A0A8V0YSR1

  9. XM_046939885.1 → XP_046795841.1  caldesmon isoform X9

    UniProtKB/TrEMBL
    A0A1L1RKY9

  10. XM_046939649.1 → XP_046795605.1  caldesmon isoform X3

    UniProtKB/TrEMBL
    A0A8V0YSR1

  11. XM_046939697.1 → XP_046795653.1  caldesmon isoform X4

  12. XM_046939594.1 → XP_046795550.1  caldesmon isoform X1

  13. XM_046939628.1 → XP_046795584.1  caldesmon isoform X2

  14. XM_046939779.1 → XP_046795735.1  caldesmon isoform X6

  15. XM_046939795.1 → XP_046795751.1  caldesmon isoform X7

  16. XM_046939767.1 → XP_046795723.1  caldesmon isoform X5

  17. XM_046939921.1 → XP_046795877.1  caldesmon isoform X10

  18. XM_046939944.1 → XP_046795900.1  caldesmon isoform X11

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    62638929..62822881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906306.1 → XP_046762262.1  caldesmon isoform X3

  2. XM_046906309.1 → XP_046762265.1  caldesmon isoform X4

    UniProtKB/Swiss-Prot
    P12957, Q03698, Q90756, Q90761, Q92018, Q99230

  3. XM_046906314.1 → XP_046762270.1  caldesmon isoform X8

  4. XM_046906316.1 → XP_046762272.1  caldesmon isoform X9

  5. XM_046906310.1 → XP_046762266.1  caldesmon isoform X4

    UniProtKB/Swiss-Prot
    P12957, Q03698, Q90756, Q90761, Q92018, Q99230

  6. XM_046906315.1 → XP_046762271.1  caldesmon isoform X8

  7. XM_046906318.1 → XP_046762274.1  caldesmon isoform X9

  8. XM_046906307.1 → XP_046762263.1  caldesmon isoform X3

  9. XM_046906317.1 → XP_046762273.1  caldesmon isoform X9

  10. XM_046906305.1 → XP_046762261.1  caldesmon isoform X3

  11. XM_046906308.1 → XP_046762264.1  caldesmon isoform X4

    UniProtKB/Swiss-Prot
    P12957, Q03698, Q90756, Q90761, Q92018, Q99230

  12. XM_046906303.1 → XP_046762259.1  caldesmon isoform X12

  13. XM_046906304.1 → XP_046762260.1  caldesmon isoform X13

  14. XM_046906312.1 → XP_046762268.1  caldesmon isoform X14

  15. XM_046906313.1 → XP_046762269.1  caldesmon isoform X15

  16. XM_046906311.1 → XP_046762267.1  caldesmon isoform X5

  17. XM_046906319.1 → XP_046762275.1  caldesmon isoform X10

  18. XM_046906320.1 → XP_046762276.1  caldesmon isoform X11

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12957.2 GenPept UniProtKB/Swiss-Prot:P12957

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