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Rbpn-5 Rabaptin-5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37395, updated on 11-Sep-2024

Summary

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Official Symbol
Rbpn-5provided by FlyBase
Official Full Name
Rabaptin-5provided by FlyBase
Primary source
FLYBASE:FBgn0034585
Locus tag
Dmel_CG4030
See related
AllianceGenome:FB:FBgn0034585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4030; Dmel\CG4030
Summary
Enables small GTPase binding activity. Involved in regulation of endosome size. Located in early endosome. Is expressed in several structures, including embryonic/larval midgut; larval ventral nerve cord; longitudinal visceral muscle primordium; and presumptive embryonic/larval system. Orthologous to human RABEP1 (rabaptin, RAB GTPase binding effector protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Rbpn-5 in Genome Data Viewer
Location:
57B19-57B19; 2-92 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21088386..21091004, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16975891..16978509, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44703 Neighboring gene antisense RNA:CR44704 Neighboring gene Chitinase 9 Neighboring gene uncharacterized protein Neighboring gene Trehalase Neighboring gene uncharacterized protein Neighboring gene Gar1 ribonucleoprotein Neighboring gene king tubby Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rabaptin-5 and Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Thomas C, et al. Dev Biol, 2014 Jan 1. PMID 24104056, Free PMC Article
  2. Mutations disrupting neuritogenesis genes confer risk for cerebral palsy. Jin SC, et al. Nat Genet, 2020 Oct. PMID 32989326, Free PMC Article
  3. Class III phosphatidylinositol-3-OH kinase controls epithelial integrity through endosomal LKB1 regulation. O'Farrell F, et al. Nat Cell Biol, 2017 Dec. PMID 29084199
  4. Oncogenic programmes and Notch activity: an 'organized crime'? Dominguez M. Semin Cell Dev Biol, 2014 Apr. PMID 24780858
  5. RNA interference analysis of Legionella in Drosophila cells: exploitation of early secretory apparatus dynamics. Dorer MS, et al. PLoS Pathog, 2006 Apr. PMID 16652170, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rabaptin-5
Names
CG4030-PA
Rabaptin5
Rbpn-5-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21088386..21091004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137701.3 → NP_611545.1  Rabaptin-5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611545.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RK4, Q9W2M0
    Related
    FBpp0071563
    Conserved Domains (4) summary
    cd15739
    Location:557 → 629
    FYVE_RABE_unchar; FYVE domain found in uncharacterized rab GTPase-binding effector proteins from bilateria
    pfam00901
    Location:336 → 473
    Orbi_VP5; Orbivirus outer capsid protein VP5
    pfam03528
    Location:37 → 374
    Rabaptin; Rabaptin
    pfam09311
    Location:256 → 555
    Rab5-bind; Rabaptin-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W2M0 Q9W2M0

Gene LinkOut

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