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VAV2 vav guanine nucleotide exchange factor 2 [ Gallus gallus (chicken) ]

Gene ID: 373938, updated on 10-Oct-2024

Summary

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Symbol
VAV2provided by CGNC
Full Name
vav guanine nucleotide exchange factor 2provided by CGNC
Primary source
CGNC:1945
See related
Ensembl:ENSGALG00010028884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See VAV2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
30
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 17 NC_052548.1 (7654387..7754756, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 17 NC_052589.1 (7065985..7165871, complement)

Chromosome 17 - NC_052548.1Genomic Context describing neighboring genes Neighboring gene ADAMTS like 2 Neighboring gene family with sequence similarity 163 member B Neighboring gene dopamine beta-hydroxylase Neighboring gene sarcosine dehydrogenase Neighboring gene uncharacterized LOC100858426 Neighboring gene bromodomain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vav3 modulates B cell receptor responses by regulating phosphoinositide 3-kinase activation. Inabe K, et al. J Exp Med, 2002 Jan 21. PMID 11805146, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV2
Names
vav 2 guanine nucleotide exchange factor
vav 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204142.2 → NP_989473.2  guanine nucleotide exchange factor VAV2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000308
    UniProtKB/TrEMBL
    Q8UUX5
    Related
    ENSGALP00010042985.1, ENSGALT00010069859.1
    Conserved Domains (7) summary
    cd10406
    Location:657 → 759
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:780 → 837
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    smart00325
    Location:197 → 370
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01223
    Location:384 → 506
    PH_Vav; Vav pleckstrin homology (PH) domain
    cd21263
    Location:2 → 120
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:509 → 566
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052548.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    7654387..7754756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901616.1 → XP_046757572.1  guanine nucleotide exchange factor VAV2 isoform X3

    Related
    ENSGALP00010042982.1, ENSGALT00010069856.1

  2. XM_046901615.1 → XP_046757571.1  guanine nucleotide exchange factor VAV2 isoform X2

  3. XM_046901614.1 → XP_046757570.1  guanine nucleotide exchange factor VAV2 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052589.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    7065985..7165871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials