U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

EDNRB2 endothelin receptor B subtype 2 [ Gallus gallus (chicken) ]

Gene ID: 373909, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Symbol
EDNRB2provided by CGNC
Full Name
endothelin receptor B subtype 2provided by CGNC
Primary source
CGNC:48952
See related
Ensembl:ENSGALG00010012311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See EDNRB2 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
10
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (11117090..11128197)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (11150890..11161855)

Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052075 Neighboring gene POU class 4 homeobox 1 like Neighboring gene RNA polymerase I subunit D Neighboring gene vesicle associated membrane protein 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Endothelin receptor B2 (EDNRB2) is responsible for the tyrosinase-independent recessive white (mo(w) ) and mottled (mo) plumage phenotypes in the chicken. Kinoshita K, et al. PLoS One, 2014. PMID 24466053, Free PMC Article
  2. Cloning and characterization of a novel endothelin receptor subtype in the avian class. Lecoin L, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501209, Free PMC Article
  3. Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition. Harris ML, et al. Development, 2008 Dec. PMID 19004859
  4. Expression of endothelin receptors in frog, chicken, mouse and human pigment cells. Scarparo AC, et al. Comp Biochem Physiol A Mol Integr Physiol, 2007 Jul. PMID 16962346

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations of EDNRB2 may cause defective binding of the protein with endothelins, which interferes with melanocyte differentiation, proliferation, and migration.
    Title: Endothelin receptor B2 (EDNRB2) is responsible for the tyrosinase-independent recessive white (mo(w) ) and mottled (mo) plumage phenotypes in the chicken.
  2. the requirement for EDNRB2 and EphB2 expression by melanoblasts is to support their migration by helping them to overcome repulsive or non-permissive cues in the dorsolateral environment
    Title: Directing pathfinding along the dorsolateral path - the role of EDNRB2 and EphB2 in overcoming inhibition.
  3. ET receptors in pigment cells of vertebrate species were identified by RT-PCR assays, and the differential expression of the various subtypes in each species was compared by quantitative PCR.
    Title: Expression of endothelin receptors in frog, chicken, mouse and human pigment cells.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endothelin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vasoconstriction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
endothelin receptor B subtype 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204120.2 → NP_989451.1  endothelin receptor B subtype 2 precursor

    See identical proteins and their annotated locations for NP_989451.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000071
    UniProtKB/TrEMBL
    F6SBA2, Q8JHV3, W8VUK4
    Conserved Domains (1) summary
    pfam00001
    Location:107 → 373
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    11117090..11128197
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046939813.1 → XP_046795769.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    F6SBA2, Q8JHV3, W8VUK4

  2. XM_040698651.2 → XP_040554585.1  endothelin receptor B subtype 2 isoform X3

    UniProtKB/TrEMBL
    F6SB94, W8VUK4
    Related
    ENSGALP00010017128.1, ENSGALT00010029471.1
    Conserved Domains (1) summary
    cd15977
    Location:121 → 416
    7tmA_ET-CR; endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_015278150.4 → XP_015133636.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    F6SBA2, Q8JHV3, W8VUK4
    Conserved Domains (1) summary
    pfam00001
    Location:107 → 373
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  4. XM_015278151.4 → XP_015133637.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    F6SBA2, Q8JHV3, W8VUK4
    Conserved Domains (1) summary
    pfam00001
    Location:107 → 373
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  5. XM_015278146.4 → XP_015133632.1  endothelin receptor B subtype 2 isoform X2

    Conserved Domains (2) summary
    pfam00001
    Location:150 → 377
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:142 → 191
    7tm_4; Olfactory receptor

  6. XM_046939812.1 → XP_046795768.1  endothelin receptor B subtype 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UCL4, W8VUK4

  7. XM_015278145.4 → XP_015133631.1  endothelin receptor B subtype 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2UCL4, W8VUK4
    Related
    ENSGALP00010017131.1, ENSGALT00010029474.1
    Conserved Domains (1) summary
    pfam00001
    Location:150 → 416
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RNA

  1. XR_006939029.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    11150890..11161855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046915337.1 → XP_046771293.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    W8VUK4

  2. XM_046915335.1 → XP_046771291.1  endothelin receptor B subtype 2 isoform X3

    UniProtKB/TrEMBL
    W8VUK4

  3. XM_046915336.1 → XP_046771292.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    W8VUK4

  4. XM_046915338.1 → XP_046771294.1  endothelin receptor B subtype 2 isoform X4

    UniProtKB/TrEMBL
    W8VUK4

  5. XM_046915334.1 → XP_046771290.1  endothelin receptor B subtype 2 isoform X2

  6. XM_046915332.1 → XP_046771288.1  endothelin receptor B subtype 2 isoform X1

    UniProtKB/TrEMBL
    W8VUK4

  7. XM_046915333.1 → XP_046771289.1  endothelin receptor B subtype 2 isoform X1

    UniProtKB/TrEMBL
    W8VUK4

RNA

  1. XR_006934325.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials