TNFRSF10B tumor necrosis factor receptor superfamily, member 10b [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: TNFRSF10Bprovided by CGNC
Official Full Name: tumor necrosis factor receptor superfamily, member 10bprovided by CGNC
Primary source: CGNC:48951
See related: Ensembl:ENSGALG00010019652
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: TVB
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Genomic context

Location:: chromosome: 22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	22	NC_052553.1 (1325172..1331767)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	22	NC_052594.1 (1338517..1345141)

Chromosome 22 - NC_052553.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The tvb gene encodes the cellular receptor necessary for subgroup B, D, and E ALV infection. Two tvb allelic variants that resulted from frameshift mutations have been identified in this study, which have been shown to have significantly reduced functionality in mediating subgroup B, D, and E ALV infection.
Title: Naturally Occurring Frameshift Mutations in the tvb Receptor Gene Are Responsible for Decreased Susceptibility of Chicken to Infection with Avian Leukosis Virus Subgroups B, D, and E.
The heterozygote tva(s1/r1) and the resistant genotype tva(r2/r2), tva(r3/r3), and tva(r4/r4) were detected in Chinese chickens by direct sequencing. The resistant genotype tvb(r/r) was detected in JNBRC, CB07, CB12, CB14, and CB15 by pyrosequencing.
Title: Single nucleotide polymorphism variants within tva and tvb receptor genes in Chinese chickens.
Amino acid 62 is cys for TvbS1 (AAF60221), ser for TvbS3 (AAD47256). TvbS1 binds ASLV (B)&(E) while TvbS3 binds ASLV(B). while the cys to ser change negates the ability to bind ASLV(E), the receptor still binds ASLV(B)
Title: Identification and characterization of a shared TNFR-related receptor for subgroup B, D, and E avian leukosis viruses reveal cysteine residues required specifically for subgroup E viral entry.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables TRAIL binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in TRAIL-activated apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 10B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204115.3 → NP_989446.2 tumor necrosis factor receptor superfamily member 10B precursor

See identical proteins and their annotated locations for NP_989446.2

Status: VALIDATED

Source sequence(s)

AF161713, JAENSK010000331

UniProtKB/TrEMBL

F1NRT6, Q9IAR7, Q9PW79

Related

ENSGALP00010028099.1, ENSGALT00010047429.1

Conserved Domains (2) summary

cd08315
Location:276 → 363

Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors

cd10580
Location:42 → 144

TNFRSF10; Tumor necrosis factor receptor superfamily member 10 (TNFRSF10), includes TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1325172..1331767

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

1338517..1345141

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046931551.1 → XP_046787507.1 tumor necrosis factor receptor superfamily member 10B isoform X1

UniProtKB/TrEMBL

Q9PW79
XM_046931552.1 → XP_046787508.1 tumor necrosis factor receptor superfamily member 10B isoform X2