hmx3.L H6 family homeobox 3 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: hmx3.L
Official Full Name: H6 family homeobox 3 L homeolog
Primary source: Xenbase:XB-GENE-865014
Locus tag: XELAEV_18034543mg
See related: EnsemblRapid:ENSXLAG00005011379 AllianceGenome:Xenbase:XB-GENE-865014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: hmx3; nkx5-1; nkx5.1; nkx-5.1; nkx-5.1-A
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in dermal system; ectoderm; nervous system; sensory system; and vestibuloauditory system. Orthologous to human HMX3 (H6 family homeobox 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 7L

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7L	NC_054383.1 (14811517..14813792, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7L	NC_030736.1 (14847102..14849377, complement)

Chromosome 7L - NC_054383.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a role of stage-specific inhibitor of Xanf-1 in the anterior neural plate during the Xenopus development
Title: The homeodomain-containing transcription factor X-nkx-5.1 inhibits expression of the homeobox gene Xanf-1 during the Xenopus laevis forebrain development.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein HMX3

Names: Nkx-5.1 homeodomain protein; X-nkx-5.1; homeobox protein H6 family member 3; homeobox protein Nkx-5.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085757.1 → NP_001079226.1 homeobox protein HMX3

See identical proteins and their annotated locations for NP_001079226.1

Status: PROVISIONAL

Source sequence(s)

AF368235

UniProtKB/Swiss-Prot

A9JS82, Q8JJ64

UniProtKB/TrEMBL

A0A974CFC1, B7ZPU3

Related

ENSXLAP00005033316.1, ENSXLAT00005034141.1

Conserved Domains (1) summary

pfam00046
Location:181 → 234

Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

14811517..14813792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)