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pomc.S proopiomelanocortin S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373802, updated on 18-Sep-2024

Summary

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Official Symbol
pomc.S
Official Full Name
proopiomelanocortin S homeolog
Primary source
Xenbase:XB-GENE-6252423
Locus tag
XELAEV_18030230mg
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
ACTH; aMSH; pomc; pomc-a; pomc-b; pomcb-A; alpha-MSH
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Genomic context

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See pomc.S in Genome Data Viewer
Location:
chromosome: 5S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5S NC_054380.1 (139472881..139479599, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5S NC_030733.1 (132806039..132812750, complement)

Chromosome 5S - NC_054380.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 S homeolog Neighboring gene EFR3 homolog B S homeolog Neighboring gene uncharacterized LOC121394328 Neighboring gene stathmin 4 S homeolog Neighboring gene protein tyrosine kinase 2 beta S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural organization of the proopiomelanocortin gene in Xenopus laevis. 5'-end homologies within the toad and mammalian genes. Martens GJ. Eur J Biochem, 1987 Jun 1. PMID 3595598
  2. Structural analysis of the entire proopiomelanocortin gene of Xenopus laevis. Deen PM, et al. Eur J Biochem, 1991 Oct 1. PMID 1915355
  3. Expression of two proopiomelanocortin genes in the pituitary gland of Xenopus laevis: complete structures of the two preprohormones. Martens GJ. Nucleic Acids Res, 1986 May 12. PMID 3754961, Free PMC Article
  4. Particular processing of pro-opiomelanocortin in Xenopus laevis intermediate pituitary. Sequencing of alpha- and beta-melanocyte-stimulating hormones. Rouillé Y, et al. FEBS Lett, 1989 Mar 13. PMID 2564347
  5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of corticosterone secretion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pro-opiomelanocortin B
Names
Corticotropin-lipotropin B
adrenocorticotropic hormone
alpha-melanophore stimulating hormone
corticotropin
proopiomelanocortin-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163390.1 → NP_001156862.1  pro-opiomelanocortin B precursor

    See identical proteins and their annotated locations for NP_001156862.1

    Status: PROVISIONAL

    Source sequence(s)
    X03844
    UniProtKB/Swiss-Prot
    P06299
    UniProtKB/TrEMBL
    A0A974CTC5
    Conserved Domains (4) summary
    pfam00976
    Location:211 → 229
    ACTH_domain; Corticotropin ACTH domain
    pfam08035
    Location:230 → 257
    Op_neuropeptide; Opioids neuropeptide
    pfam08384
    Location:27 → 69
    NPP; Pro-opiomelanocortin, N-terminal region
    pfam16102
    Location:108 → 134
    ACTH_assoc; ACTH-associated domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054380.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    139472881..139479599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06299.1 GenPept UniProtKB/Swiss-Prot:P06299

Gene LinkOut

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