mitf.L melanocyte inducing transcription factor L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: mitf.L
Official Full Name: melanocyte inducing transcription factor L homeolog
Primary source: Xenbase:XB-GENE-6252679
Locus tag: XELAEV_18024102mg
See related: EnsemblRapid:ENSXLAG00005005926
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mitf; mitfa; mitf-a; mitf-b
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 4L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (142617654..142674243, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (137379456..137436128, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XlMitf plays a central role in the development of melanin-producing cell lineages
Title: Isolation and developmental expression of Mitf in Xenopus laevis.
induction of ectopic retinal pigment epithelium (RPE) and extended RPE by overexpression of XlMitfalpha-M and possible interactions between XlMitfalpha and several eye-related genes essential for normal eye development
Title: Regulation of melanoblast and retinal pigment epithelium development by Xenopus laevis Mitf.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within melanocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanocyte inducing transcription factor L homeolog

Names: microphthalmia-associated transcription factor A; microphthalmia-associated transcription factor L homeolog; microphthalmia-associated transcription factor L homeolog type A transcript; microphthalmia-associated transcription factor L homeolog type M transcript

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172175.1 → NP_001165646.1 melanocyte inducing transcription factor L homeolog

See identical proteins and their annotated locations for NP_001165646.1

Status: PROVISIONAL

Source sequence(s)

AB108426

UniProtKB/TrEMBL

A0A2C9DXU0, Q76DN4

Related

ENSXLAP00005017756.1, ENSXLAT00005018052.1

Conserved Domains (3) summary

cd00083
Location:269 → 329

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam11851
Location:357 → 480

DUF3371; Domain of unknown function (DUF3371)

pfam15951
Location:56 → 194

MITF_TFEB_C_3_N; MITF/TFEB/TFEC/TFE3 N-terminus

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

142617654..142674243 complement

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GenBank, FASTA, Sequence Viewer (Graphics)