sim2.S SIM bHLH transcription factor 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sim2.S
Official Full Name: SIM bHLH transcription factor 2 S homeolog
Primary source: Xenbase:XB-GENE-1013959
Locus tag: XELAEV_18014330mg
See related: EnsemblRapid:ENSXLAG00005024559 AllianceGenome:Xenbase:XB-GENE-1013959
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sim2; xSim; Xsim2; sim2-A
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of transcription by RNA polymerase II. Is expressed in ectoderm; musculoskeletal system; nervous system; and pharyngeal arch. Orthologous to human SIM2 (SIM bHLH transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (21371380..21424319)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (21328323..21381281)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within system development	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SIM bHLH transcription factor 2 S homeolog

Names: single-minded family bHLH transcription factor 2 S homeolog; single-minded homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085632.2 → NP_001079101.1 SIM bHLH transcription factor 2 S homeolog

See identical proteins and their annotated locations for NP_001079101.1

Status: PROVISIONAL

Source sequence(s)

AF283298

UniProtKB/TrEMBL

A0A974HUY7, Q9DDU6

Related

ENSXLAP00005072774.1, ENSXLAT00005074333.1

Conserved Domains (5) summary

cd00083
Location:2 → 52

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

cd00130
Location:229 → 328

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:79 → 159

PAS; PAS fold

pfam06621
Location:359 → 635

SIM_C; Single-minded protein C-terminus

pfam08447
Location:243 → 329

PAS_3; PAS fold

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

21371380..21424319

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041582958.1 → XP_041438892.1 SIM bHLH transcription factor 2 S homeolog isoform X1

UniProtKB/TrEMBL

A0A8J1MB09, A0A974HUY7

Conserved Domains (3) summary

smart00091
Location:182 → 243

PAS; PAS domain

pfam08447
Location:346 → 432

PAS_3; PAS fold

cd11434
Location:1 → 60

bHLH-PAS_SIM; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded (SIM) family