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hhex.L hematopoietically expressed homeobox L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 373590, updated on 4-Nov-2024

Summary

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Official Symbol
hhex.L
Official Full Name
hematopoietically expressed homeobox L homeolog
Primary source
Xenbase:XB-GENE-865680
Locus tag
XELAEV_18034597mg
See related
EnsemblRapid:ENSXLAG00005011531 AllianceGenome:Xenbase:XB-GENE-865680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
hex; prh; Hex1; XHex; prhx; tHex; hhex-A
Summary
Predicted to enable sequence-specific DNA binding activity. Acts upstream of or within several processes, including circulatory system development; liver development; and positive regulation of Wnt signaling pathway. Predicted to be located in nucleus. Is expressed in anatomical system; pharyngeal arch; and primary germ layer. Orthologous to human HHEX (hematopoietically expressed homeobox). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hhex.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (20337517..20351524, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (20384473..20398490, complement)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 26 subfamily C member 1 L homeolog Neighboring gene exocyst complex component 6 L homeolog Neighboring gene kinesin family member 11 L homeolog Neighboring gene insulin degrading enzyme L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. Rankin SA, et al. Dev Biol, 2011 Mar 15. PMID 21215263, Free PMC Article
  2. Xhex-expressing endodermal tissues are essential for anterior patterning in Xenopus. Smithers LE, et al. Mech Dev, 2002 Dec. PMID 12464432
  3. An anterior signalling centre in Xenopus revealed by the homeobox gene XHex. Jones CM, et al. Curr Biol, 1999 Sep 9. PMID 10508583
  4. Anterior endomesoderm specification in Xenopus by Wnt/beta-catenin and TGF-beta signalling pathways. Zorn AM, et al. Dev Biol, 1999 May 15. PMID 10328921
  5. The XHex homeobox gene is expressed during development of the vascular endothelium: overexpression leads to an increase in vascular endothelial cell number. Newman CS, et al. Mech Dev, 1997 Aug. PMID 9376326

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that knockdown of hematopoietically expressed homeobox (hhex) resulted in a down-regulation of ventral pancreatic precursor 1 (vpp1) expression and a specific loss of the ventral pancreas.
    Title: Homeoprotein hhex-induced conversion of intestinal to ventral pancreatic precursors results in the formation of giant pancreata in Xenopus embryos.
  2. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
    Title: A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC69042

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anterior/posterior pattern specification IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within embryonic hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within liver development IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
hematopoietically-expressed homeobox protein hhex
Names
hhex
homeobox protein hex

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085590.1 → NP_001079059.1  hematopoietically-expressed homeobox protein hhex

    See identical proteins and their annotated locations for NP_001079059.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059320
    UniProtKB/Swiss-Prot
    O13023
    UniProtKB/TrEMBL
    A0A974CE99
    Related
    ENSXLAP00005033744.1, ENSXLAT00005034583.1
    Conserved Domains (1) summary
    pfam00046
    Location:143 → 193
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    20337517..20351524 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O13023.1 GenPept UniProtKB/Swiss-Prot:O13023

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials