hts hu li tai shao [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: htsprovided by FlyBase
Official Full Name: hu li tai shaoprovided by FlyBase
Primary source: FLYBASE:FBgn0263391
Locus tag: Dmel_CG43443
See related: AllianceGenome:FB:FBgn0263391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1B1; add; Add; ADD-87; Add-hts; add-like; Add1; Add2; adducin; Adducin; anon-EST:Posey9; CG34197; CG43443; CG9325; Dmel\CG43443; EST D; Hts; HTS; HTS-R1; Hts-RC; HTS-RC; HtsF; htsRC; HtsRC; HTS_DROME; l(2)00634; l(2)01103; l(2)k06121; l(2)k14523; Ovhts; Ovhts-RC; sxp
Old locus tag: Dmel_CG34197; Dmel_CG9325
Summary: Predicted to enable actin filament binding activity. Involved in several processes, including adult somatic muscle development; cytoskeleton organization; and fusome organization. Located in several cellular components, including fusome; germline ring canal; and spectrosome. Is active in postsynapse and presynapse. Colocalizes with actin filament. Is expressed in several structures, including epithelium; fusome; germline cell; gonad; and somatic cell of ovariole. Used to study cerebral palsy and spastic quadriplegic cerebral palsy 3. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; gastroschisis; and spastic quadriplegic cerebral palsy 3. Orthologous to human ADD1 (adducin 1); ADD2 (adducin 2); and ADD3 (adducin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 56D3-56D5; 2-89 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19397032..19424903, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15284537..15312408, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HtsRC-Mediated Accumulation of F-Actin Regulates Ring Canal Size During Drosophila melanogaster Oogenesis.
Title: HtsRC-Mediated Accumulation of F-Actin Regulates Ring Canal Size During Drosophila melanogaster Oogenesis.
Screen for novel regulators of synapse morphogenesis at the larval neuromuscular junction in Drosophila identified miR-34 as conserved synapse-regulatory miRNA and junctional receptor CNTNAP4/Neurexin-IV (Nrx-IV) and the membrane cytoskeletal effector Adducin/Hu-li tai shao (Hts) as proteins whose synaptic expression is restricted by miR-34.
Title: The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells.
Swa is crucial for the organization of actin networks that lead to the formation of a specialized microtubule population, while Ovhts-RC acts to modulate spatially restricted actin filament growth at the oocyte cortex.
Title: Distinct roles for hu li tai shao and swallow in cytoskeletal organization during Drosophila oogenesis.
Knocking out of hts gene causes locomotion deficits in Drosophila flies.
Title: Mutations in γ adducin are associated with inherited cerebral palsy.
Hts regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.
Title: Drosophila adducin regulates Dlg phosphorylation and targeting of Dlg to the synapse and epithelial membrane.
We propose that phosphorylation-dependent regulation of Hts/Adducin controls the level, localization, and activity of Hts/Adducin, influencing actin-based synapse elaboration and spectrin-based synapse stabilization.
Title: Hts/Adducin controls synaptic elaboration and elimination.
Gogo both positively and negatively regulates Hts that affects the Actin-Spectrin cytoskeleton in growth cone filopodia, thereby guiding photoreceptor axons.
Title: Hts, the Drosophila homologue of Adducin, physically interacts with the transmembrane receptor Golden goal to guide photoreceptor axons.
results indicate that hts function is necessary for centrosome inheritance in spermatocytes as well as for male fertility
Title: Centrosome inheritance in the male germ line of Drosophila requires hu-li tai-shao function.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0803 (e-PCR)
- UniSTS:3670

Dm0326 (e-PCR)
- UniSTS:32393

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament bundle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult somatic muscle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cystoblast division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line cyst formation	TAS Traceable Author Statement more info	PubMed
involved_in female germline ring canal formation, actin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation, actin assembly	TAS Traceable Author Statement more info	PubMed
involved_in fusome organization	TAS Traceable Author Statement more info	PubMed
involved_in germ-line cyst formation	TAS Traceable Author Statement more info	PubMed
involved_in germarium-derived oocyte fate determination	TAS Traceable Author Statement more info	PubMed
involved_in meiotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in photoreceptor cell axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in photoreceptor cell axon guidance	IPI Inferred from Physical Interaction more info	PubMed
involved_in postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in testicular fusome organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in female germline ring canal inner rim	TAS Traceable Author Statement more info	PubMed
located_in fusome	IDA Inferred from Direct Assay more info	PubMed
located_in fusome	TAS Traceable Author Statement more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	TAS Traceable Author Statement more info	PubMed
located_in lateral plasma membrane	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in spectrosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hu li tai shao

Names: Adducin-like 56D; Adducin-like-56D; CG43443-PA; CG43443-PC; CG43443-PD; CG43443-PH; CG43443-PI; CG43443-PJ; CG43443-PK; CG43443-PL; CG43443-PM; CG43443-PN; CG43443-PO; CG43443-PP; CG43443-PQ; CG43443-PR; CG43443-PS; CG43443-PT; Hu Li Tai shao; Hu li-tai shao; Hu-li tai shao; Hu-li tai-shao; adducin; adducin-like; hts-PA; hts-PC; hts-PD; hts-PH; hts-PI; hts-PJ; hts-PK; hts-PL; hts-PM; hts-PN; hts-PO; hts-PP; hts-PQ; hts-PR; hts-PS; hts-PT; hu-li tai shao protein; hu-li-tai-shao; ovarian hu-li tai shao-ring canal protein

NP_725886.2

unusual splice

NP_725887.2

unusual splice

NP_725888.2

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19397032..19424903 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202048.3 → NP_001188977.2 hu li tai shao, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188977.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7A5

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001259491.2 → NP_001246420.1 hu li tai shao, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246420.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K849

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001299683.1 → NP_001286612.1 hu li tai shao, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286612.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K849

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001259492.2 → NP_001246421.1 hu li tai shao, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246421.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7A5

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_166348.3 → NP_725887.2 hu li tai shao, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725887.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_166349.3 → NP_725888.2 hu li tai shao, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725888.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_166347.3 → NP_725886.2 hu li tai shao, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725886.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_057529.4 → NP_476877.1 hu li tai shao, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476877.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5

Related

FBpp0301112

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001169734.2 → NP_001163205.1 hu li tai shao, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163205.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001169735.2 → NP_001163206.1 hu li tai shao, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163206.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1ZBK8, A4UZP6, E1JGM4, E1JGM6, Q02645, Q8MQX6, Q9GNA8, Q9GZC1, Q9V8U4, Q9V8U5

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001103907.3 → NP_001097377.2 hu li tai shao, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097377.2

Status: REVIEWED

UniProtKB/TrEMBL

A8DYJ2

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_166350.2 → NP_725889.1 hu li tai shao, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725889.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Related

FBpp0301110

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001382109.1 → NP_001369098.1 hu li tai shao, isoform T [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A6M3Q7Q7

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_166351.2 → NP_725890.1 hu li tai shao, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725890.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Related

FBpp0301111

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001169732.2 → NP_001163203.1 hu li tai shao, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163203.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001169733.2 → NP_001163204.1 hu li tai shao, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q02645

Conserved Domains (1) summary

cd00398
Location:116 → 323

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...