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B1R temporal expression: early [ Vaccinia virus ]

Gene ID: 3707654, updated on 18-Aug-2023

Summary

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Gene symbol
B1R
Gene description
temporal expression: early
Locus tag
VACWR183
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Vaccinia virus (strain: WR (Western Reserve))
Lineage
Viruses; dsDNA viruses, no RNA stage; Poxviridae; Chordopoxvirinae; Orthopoxvirus
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Genomic context

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Sequence:
NC_006998.1 (163878..164780)

NC_006998.1Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene guanylate kinase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_006998.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase. Jha S, et al. Nature, 2017 Jun 29. PMID 28636603, Free PMC Article
  2. Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2. Olson AT, et al. J Virol, 2017 Aug 1. PMID 28515294, Free PMC Article
  3. Vaccinia Virus B1 Kinase Is Required for Postreplicative Stages of the Viral Life Cycle in a BAF-Independent Manner in U2OS Cells. Jamin A, et al. J Virol, 2015 Oct. PMID 26223647, Free PMC Article
  4. Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase. Ibrahim N, et al. Virology, 2013 Sep. PMID 23891157, Free PMC Article
  5. Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication. Wiebe MS, et al. Cell Host Microbe, 2007 May 17. PMID 18005698, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase, vaccinia virus B1
    Title: Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase.
  2. These data support a model in which vaccinia virus B1 and human VRK2 share additional substrates important for the replication of cytoplasmic poxviruses.
    Title: Deletion of the Vaccinia Virus B1 Kinase Reveals Essential Functions of This Enzyme Complemented Partly by the Homologous Cellular Kinase VRK2.
  3. Vaccinia virus B1 kinase is needed for multiple critical junctures in the poxviral life cycle in a manner that is both dependent on and independent of BAF.
    Title: Vaccinia Virus B1 Kinase Is Required for Postreplicative Stages of the Viral Life Cycle in a BAF-Independent Manner in U2OS Cells.
  4. The decrease in vaccinia virus transcription caused by loss of B1 kinase can be rescued by depletion of BAF.
    Title: Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase.
  5. We now show that BAF acts as a potent inhibitor of poxvirus replication unless its DNA-binding activity is blocked by B1-mediated phosphorylation.
    Title: Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

General protein information

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Preferred Names
ser/thr kinase
YP_233065.1
  • similar to VACCP-B1R; essential for viral DNA replication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006998.1 Reference assembly

    Range
    163878..164780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_233065.1 ser/thr kinase [Vaccinia virus]

    See identical proteins and their annotated locations for YP_233065.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P16913, P20505, Q76ZM2
    UniProtKB/TrEMBL
    A0A0A7A5W6, A0A2I2MCC1, A0A2P1JPW9, A9J127, Q1PIL7, Q6RZC6, Q77TG5
    Conserved Domains (1) summary
    cl21453
    Location:5 → 294
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
AAO89462.1

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