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ITGB8 integrin subunit beta 8 [ Homo sapiens (human) ]

Gene ID: 3696, updated on 2-Nov-2024

Summary

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Official Symbol
ITGB8provided by HGNC
Official Full Name
integrin subunit beta 8provided by HGNC
Primary source
HGNC:HGNC:6163
See related
Ensembl:ENSG00000105855 MIM:604160; AllianceGenome:HGNC:6163
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the integrin beta chain family and encodes a single-pass type I membrane protein with a VWFA domain and four cysteine-rich repeats. This protein noncovalently binds to an alpha subunit to form a heterodimeric integrin complex. In general, integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in kidney (RPKM 12.1), brain (RPKM 11.6) and 19 other tissues See more
Orthologs
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Genomic context

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See ITGB8 in Genome Data Viewer
Location:
7p21.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (20329766..20415754)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (20464766..20550710)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (20370523..20455377)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:20256832-20258031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:20259517-20260046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25691 Neighboring gene glutamine insufficiency regulator of glutaminase lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25692 Neighboring gene uncharacterized LOC101927769 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:20369144-20369756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17991 Neighboring gene ITGB8 antisense RNA 1 Neighboring gene small nucleolar RNA SNORD56 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:20434600-20435799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:20526689-20527188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:20599105-20599605 Neighboring gene Sharpr-MPRA regulatory region 1382 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 27 Neighboring gene RAS like proto-oncogene A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling. Lin X, et al. Mol Ther, 2022 Feb 2. PMID 34371180, Free PMC Article
  2. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin. Tchaicha JH, et al. Cancer Res, 2011 Oct 15. PMID 21859829, Free PMC Article
  3. Integrin Subunit beta 8 (ITGB8) Upregulation Is an Independent Predictor of Unfavorable Survival of High-Grade Serous Ovarian Carcinoma Patients. He J, et al. Med Sci Monit, 2018 Dec 10. PMID 30531684, Free PMC Article
  4. Alteration in metastasis potential and gene expression in human lung cancer cell lines by ITGB8 silencing. Xu Z, et al. Anat Rec (Hoboken), 2012 Sep. PMID 22753015
  5. Integrin subunit beta 8 contributes to lenvatinib resistance in HCC. Hou W, et al. Hepatol Commun, 2022 Jul. PMID 35238496, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interaction of Integrin alphavbeta8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.
    Title: Interaction of Integrin αvβ8 With Type I Collagen Promotes Squamous Cell Carcinoma Cell Motility via RAC1 Activation.
  2. Specificity of TGF-beta1 signal designated by LRRC33 and integrin alphaVbeta8.
    Title: Specificity of TGF-β1 signal designated by LRRC33 and integrin α(V)β(8).
  3. Integrin subunit beta 8 contributes to lenvatinib resistance in HCC.
    Title: Integrin subunit beta 8 contributes to lenvatinib resistance in HCC.
  4. Paradoxical role of beta8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma.
    Title: Paradoxical role of β8 integrin on angiogenesis and vasculogenic mimicry in glioblastoma.
  5. lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling.
    Title: lncRNA ITGB8-AS1 functions as a ceRNA to promote colorectal cancer growth and migration through integrin-mediated focal adhesion signaling.
  6. Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma.
    Title: Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma.
  7. The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells.
    Title: The long non-coding RNA PVT1/miR-145-5p/ITGB8 axis regulates cell proliferation, apoptosis, migration and invasion in non-small cell lung cancer cells.
  8. Data uncovered that ITGB8 was a target gene of miR-106b. ITGB8 mRNA and protein levels decreased in colon cancer cells overexpressing miR-106b.
    Title: Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p.
  9. ITGB8 gene SNPs may be implicated in the risk of hemorrhagic event after a traumatic brain injury.
    Title: Effect of integrin AV and B8 gene polymorphisms in patients with traumatic brain injury.
  10. Lack of a binding site for one of three betaI domain divalent cations and a unique beta6-alpha7 loop conformation in beta8 facilitate movements of the alpha1 and alpha1' helices at the ligand binding pocket toward the high affinity state.
    Title: General structural features that regulate integrin affinity revealed by atypical αVβ8.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Langerhans cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell-matrix adhesion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ganglioside metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in hard palate development IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in placenta blood vessel development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
  
involved_in transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vasculogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of integrin alphav-beta8 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrin alphav-beta8 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
integrin beta-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002214.3 → NP_002205.1  integrin beta-8 precursor

    See identical proteins and their annotated locations for NP_002205.1

    Status: REVIEWED

    Source sequence(s)
    AC004130, AW516961, BC002630, BI861225, M73780
    Consensus CDS
    CCDS5370.1
    UniProtKB/Swiss-Prot
    A4D133, B4DHD4, P26012
    Related
    ENSP00000222573.3, ENST00000222573.5
    Conserved Domains (1) summary
    smart00187
    Location:54 → 469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    20329766..20415754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515393.3 → XP_011513695.1  integrin beta-8 isoform X2

    Conserved Domains (1) summary
    smart00187
    Location:46 → 461
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

  2. XM_017012179.2 → XP_016867668.1  integrin beta-8 isoform X1

    UniProtKB/Swiss-Prot
    A4D133, B4DHD4, P26012
    Conserved Domains (1) summary
    smart00187
    Location:54 → 469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

  3. XM_047420345.1 → XP_047276301.1  integrin beta-8 isoform X4

  4. XM_047420341.1 → XP_047276297.1  integrin beta-8 isoform X4

  5. XM_011515394.3 → XP_011513696.1  integrin beta-8 isoform X3

    Conserved Domains (1) summary
    smart00187
    Location:43 → 458
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

  6. XM_017012178.2 → XP_016867667.1  integrin beta-8 isoform X1

    UniProtKB/Swiss-Prot
    A4D133, B4DHD4, P26012
    Conserved Domains (1) summary
    smart00187
    Location:54 → 469
    INB; Integrin beta subunits (N-terminal portion of extracellular region)

  7. XM_047420342.1 → XP_047276298.1  integrin beta-8 isoform X4

  8. XM_047420343.1 → XP_047276299.1  integrin beta-8 isoform X4

  9. XM_017012183.2 → XP_016867672.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Related
    ENSP00000441561.1, ENST00000537992.5
    Conserved Domains (1) summary
    cl00057
    Location:1 → 334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  10. XM_017012182.2 → XP_016867671.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1 → 334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  11. XM_017012180.2 → XP_016867669.1  integrin beta-8 isoform X4

    UniProtKB/Swiss-Prot
    P26012
    Conserved Domains (1) summary
    cl00057
    Location:1 → 334
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  12. XM_047420344.1 → XP_047276300.1  integrin beta-8 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    20464766..20550710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358160.1 → XP_054214135.1  integrin beta-8 isoform X2

  2. XM_054358162.1 → XP_054214137.1  integrin beta-8 isoform X4

  3. XM_054358161.1 → XP_054214136.1  integrin beta-8 isoform X3

  4. XM_054358163.1 → XP_054214138.1  integrin beta-8 isoform X4

  5. XM_054358164.1 → XP_054214139.1  integrin beta-8 isoform X4

  6. XM_054358165.1 → XP_054214140.1  integrin beta-8 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26012.1 GenPept UniProtKB/Swiss-Prot:P26012

Gene LinkOut

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