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Adck1 aarF domain containing kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 366698, updated on 17-Aug-2024

Summary

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Official Symbol
Adck1provided by RGD
Official Full Name
aarF domain containing kinase 1provided by RGD
Primary source
RGD:1308263
See related
EnsemblRapid:ENSRNOG00000012685 AllianceGenome:RGD:1308263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in lipid homeostasis; mitochondrion organization; and regulation of mitochondrion organization. Predicted to be active in mitochondrial inner membrane. Predicted to be integral component of mitochondrial membrane. Orthologous to human ADCK1 (aarF domain containing kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 29.0), Heart (RPKM 24.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (113005333..113107960)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (107277170..107377057)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (111640652..111741418)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene WW domain-binding protein 11-like Neighboring gene GLE1 RNA export mediator, pseudogene 8 Neighboring gene uncharacterized LOC120103589 Neighboring gene U6 spliceosomal RNA Neighboring gene ligand dependent nuclear receptor interacting factor, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle. Yoon W, et al. PLoS Genet, 2019 May. PMID 31125351, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mitochondrial fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cristae formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aarF domain-containing protein kinase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108985.2 → NP_001102455.1  aarF domain-containing protein kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001102455.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6JEB5, D3ZRJ0
    Related
    ENSRNOP00000016962.4, ENSRNOT00000016962.7
    Conserved Domains (2) summary
    COG0661
    Location:74 → 450
    AarF; Predicted unusual protein kinase regulating ubiquinone biosynthesis, AarF/ABC1/UbiB family [Coenzyme transport and metabolism, Signal transduction mechanisms]
    cd13969
    Location:74 → 301
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  2. NM_001399747.1 → NP_001386676.1  aarF domain-containing protein kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5Y874
    Related
    ENSRNOP00000078150.1, ENSRNOT00000104832.2

  3. NM_001399748.1 → NP_001386677.1  aarF domain-containing protein kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I5Y874
    Related
    ENSRNOP00000105674.1, ENSRNOT00000134547.1

  4. NM_001399749.1 → NP_001386678.1  aarF domain-containing protein kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

  5. NM_001399750.1 → NP_001386679.1  aarF domain-containing protein kinase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    113005333..113107960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112658.2 → XP_038968586.1  aarF domain-containing protein kinase 1 isoform X2

    Conserved Domains (1) summary
    cd13969
    Location:1 → 243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  2. XM_039112651.2 → XP_038968579.1  aarF domain-containing protein kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y874
    Conserved Domains (1) summary
    cd13969
    Location:117 → 369
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  3. XM_039112657.2 → XP_038968585.1  aarF domain-containing protein kinase 1 isoform X2

    Related
    ENSRNOP00000107090.1, ENSRNOT00000129047.1
    Conserved Domains (1) summary
    cd13969
    Location:1 → 243
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  4. XM_039112655.2 → XP_038968583.1  aarF domain-containing protein kinase 1 isoform X3

    Conserved Domains (1) summary
    cd13969
    Location:62 → 314
    ADCK1-like; aarF domain containing kinase 1 and similar proteins

  5. XM_063262230.1 → XP_063118300.1  aarF domain-containing protein kinase 1 isoform X3

  6. XM_039112653.2 → XP_038968581.2  aarF domain-containing protein kinase 1 isoform X2

  7. XM_063262231.1 → XP_063118301.1  aarF domain-containing protein kinase 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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