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IRF7 interferon regulatory factor 7 [ Homo sapiens (human) ]

Gene ID: 3665, updated on 14-Nov-2024

Summary

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Official Symbol
IRF7provided by HGNC
Official Full Name
interferon regulatory factor 7provided by HGNC
Primary source
HGNC:HGNC:6122
See related
Ensembl:ENSG00000185507 MIM:605047; AllianceGenome:HGNC:6122
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IMD39; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
Summary
This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. The encoded protein plays an important role in the innate immune response against DNA and RNA viruses. [provided by RefSeq, Jul 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Broad expression in spleen (RPKM 16.7), lymph node (RPKM 8.9) and 24 other tissues See more
Orthologs
mouse all
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Genomic context

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See IRF7 in Genome Data Viewer
Location:
11p15.5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (612555..615950, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (661201..664566, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (612555..615950, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC143666 Neighboring gene PHD and ring finger domains 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:583763-584264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:584265-584764 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:595501-596000 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:604659-605277 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:612434-613028 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:613623-614217 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:614812-615406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:620099-620704 Neighboring gene cadherin related family member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:626715-627215 Neighboring gene secretin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Lysine residues of interferon regulatory factor 7 affect the replication and transcription activator-mediated lytic replication of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8. Zhang T, et al. J Gen Virol, 2011 Jan. PMID 20844090, Free PMC Article
  2. Upper Airway Cell Transcriptomics Identify a Major New Immunological Phenotype with Strong Clinical Correlates in Young Children with Acute Wheezing. Khoo SK, et al. J Immunol, 2019 Mar 15. PMID 30745463
  3. Suppression of the IFN-α and -β Induction through Sequestering IRF7 into Viral Inclusion Bodies by Nonstructural Protein NSs in Severe Fever with Thrombocytopenia Syndrome Bunyavirus Infection. Hong Y, et al. J Immunol, 2019 Feb 1. PMID 30598516
  4. Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer. Lan Q, et al. Oncogene, 2019 Apr. PMID 30546090, Free PMC Article
  5. Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3. Joo CH, et al. J Virol, 2007 Aug. PMID 17522209, Free PMC Article

See all (192) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.
    Title: Single-cell sequencing combined with spatial transcriptomics reveals that the IRF7 gene in M1 macrophages inhibits the occurrence of pancreatic cancer by regulating lipid metabolism-related mechanisms.
  2. Non-transcriptional IRF7 interacts with NF-kappaB to inhibit viral inflammation.
    Title: Non-transcriptional IRF7 interacts with NF-κB to inhibit viral inflammation.
  3. IRF7: role and regulation in immunity and autoimmunity.
    Title: IRF7: role and regulation in immunity and autoimmunity.
  4. Interferon regulatory factor 7 in inflammation, cancer and infection.
    Title: Interferon regulatory factor 7 in inflammation, cancer and infection.
  5. Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.
    Title: Porcine Epidemic Diarrhea Virus Membrane Protein Interacted with IRF7 to Inhibit Type I IFN Production during Viral Infection.
  6. Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection.
    Title: Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection.
  7. ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.
    Title: ERVs-TLR3-IRF axis is linked to myelodysplastic syndrome pathogenesis.
  8. M2 macrophages contribute to cell proliferation and migration of breast cancer.
    Title: M2 macrophages contribute to cell proliferation and migration of breast cancer.
  9. RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
    Title: RAGE impairs murine diabetic atherosclerosis regression and implicates IRF7 in macrophage inflammation and cholesterol metabolism.
  10. Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.
    Title: Downregulation of miR-155-5p facilitates enterovirus 71 replication through suppression of type I IFN response by targeting FOXO3/IRF7 pathway.
Submit: New GeneRIF Correction See all GeneRIFs (121)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency 39
MedGen: C4225358 OMIM: 616345 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat The interaction of HIV-1 Tat with cellular transcription factors CDK9 and Sp1 is required for Tat activation of MAP2K3-, MAP2K6-, and IRF7-mediated luciferase transcription PubMed
tat MAP2K6 and IRF7 induce HIV-1 Tat-mediated cellular gene modulation through the p38 MAPK/STAT1 pathway in immature dendritic cells and in monocyte-derived macrophages PubMed
tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including IFN regulatory factor 7A (IRF7), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
tat SiRNA-mediated inhibition of IRF7 reduces HIV-1 Tat-induced modulation of interferon (IFN)-stimulated genes in immature dendritic cells and in monocyte-derived macrophages PubMed
tat HIV-1 Tat-mediated downregulation of TRAF3 increases levels of phosphorylation of IRF3 and IRF7 in human microglial cells PubMed
Vpr vpr HIV-1 Vpr upregulates the expression of interferon regulatory factor 7 in human monocyte-derived macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response TAS
Traceable Author Statement
more info
 PubMed 
involved_in MDA-5 signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in cytoplasmic pattern recognition receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to virus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in establishment of viral latency TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immunoglobulin mediated immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of macrophage apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-alpha production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interferon-alpha production TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of interferon-beta production TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MyD88-dependent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of MyD88-independent toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of adaptive immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of immune response TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of monocyte differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of type I interferon production TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to virus TAS
Traceable Author Statement
more info
 PubMed 
involved_in type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endosome membrane TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
interferon regulatory factor 7
Names
interferon regulatory factor-7H

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029106.1 RefSeqGene

    Range
    5050..8445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1313

mRNA and Protein(s)

  1. NM_001572.5 → NP_001563.2  interferon regulatory factor 7 isoform a

    See identical proteins and their annotated locations for NP_001563.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) has an alternate exon structure in the 5' coding region, resulting in the use of an alternate start codon compared to variant d. The resulting isoform (a) is shorter and has a distinct N-terminus compared to isoform d.
    Source sequence(s)
    AF076494, BM849172, U53830, U53831, U73036
    Consensus CDS
    CCDS7703.1
    UniProtKB/Swiss-Prot
    B9EGL3, O00331, O00332, O00333, O75924, Q92985, Q9UE79
    Related
    ENSP00000434009.2, ENST00000525445.6
    Conserved Domains (2) summary
    pfam00605
    Location:13 → 124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:289 → 466
    IRF-3; Interferon-regulatory factor 3

  2. NM_004029.4 → NP_004020.1  interferon regulatory factor 7 isoform b

    See identical proteins and their annotated locations for NP_004020.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) has an alternate exon structure in the 5' coding region and lacks an alternate in-frame exon, compared to variant d. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform d.
    Source sequence(s)
    AF076494, BM849172, U53831
    Consensus CDS
    CCDS7704.1
    Related
    ENSP00000331803.9, ENST00000348655.11
    Conserved Domains (2) summary
    pfam00605
    Location:13 → 124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:260 → 437
    IRF-3; Interferon-regulatory factor 3

  3. NM_004031.4 → NP_004022.2  interferon regulatory factor 7 isoform d

    See identical proteins and their annotated locations for NP_004022.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) encodes the longest isoform (d).
    Source sequence(s)
    AF076494, BM849172, U53830, U53831, U73036
    Consensus CDS
    CCDS7705.1
    UniProtKB/Swiss-Prot
    Q92985
    Related
    ENSP00000329411.5, ENST00000330243.9
    Conserved Domains (2) summary
    pfam00605
    Location:26 → 137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:302 → 479
    IRF-3; Interferon-regulatory factor 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    612555..615950 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520066.4 → XP_011518368.1  interferon regulatory factor 7 isoform X2

    See identical proteins and their annotated locations for XP_011518368.1

    Conserved Domains (2) summary
    pfam00605
    Location:13 → 124
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:288 → 465
    IRF-3; Interferon-regulatory factor 3

  2. XM_005252907.4 → XP_005252964.1  interferon regulatory factor 7 isoform X1

    See identical proteins and their annotated locations for XP_005252964.1

    Conserved Domains (2) summary
    pfam00605
    Location:26 → 137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:301 → 478
    IRF-3; Interferon-regulatory factor 3

  3. XM_005252909.4 → XP_005252966.1  interferon regulatory factor 7 isoform X3

    See identical proteins and their annotated locations for XP_005252966.1

    UniProtKB/TrEMBL
    A0A1P8DYP2, M9RSF4
    Related
    ENSP00000380700.2, ENST00000397570.5
    Conserved Domains (2) summary
    pfam00605
    Location:26 → 137
    IRF; Interferon regulatory factor transcription factor
    pfam10401
    Location:273 → 450
    IRF-3; Interferon-regulatory factor 3

  4. XM_017017674.1 → XP_016873163.1  interferon regulatory factor 7 isoform X4

    UniProtKB/TrEMBL
    B4E1B1
    Conserved Domains (1) summary
    pfam10401
    Location:1 → 173
    IRF-3; Interferon-regulatory factor 3

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187586.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    142448..145849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328902.1 → XP_054184877.1  interferon regulatory factor 7 isoform X6

  2. XM_054328899.1 → XP_054184874.1  interferon regulatory factor 7 isoform X2

  3. XM_054328901.1 → XP_054184876.1  interferon regulatory factor 7 isoform X5

  4. XM_054328898.1 → XP_054184873.1  interferon regulatory factor 7 isoform X1

  5. XM_054328900.1 → XP_054184875.1  interferon regulatory factor 7 isoform X3

    UniProtKB/TrEMBL
    M9RSF4

  6. XM_054328903.1 → XP_054184878.1  interferon regulatory factor 7 isoform X4

    UniProtKB/TrEMBL
    B4E1B1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    661201..664566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368690.1 → XP_054224665.1  interferon regulatory factor 7 isoform X8

  2. XM_054368687.1 → XP_054224662.1  interferon regulatory factor 7 isoform X2

  3. XM_054368689.1 → XP_054224664.1  interferon regulatory factor 7 isoform X7

  4. XM_054368686.1 → XP_054224661.1  interferon regulatory factor 7 isoform X1

  5. XM_054368688.1 → XP_054224663.1  interferon regulatory factor 7 isoform X3

  6. XM_054368691.1 → XP_054224666.1  interferon regulatory factor 7 isoform X4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_004030.1: Suppressed sequence

    Description
    NM_004030.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92985.2 GenPept UniProtKB/Swiss-Prot:Q92985

Gene LinkOut

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