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St6galnac5 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365984, updated on 17-Aug-2024

Summary

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Official Symbol
St6galnac5provided by RGD
Official Full Name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5provided by RGD
Primary source
RGD:1564252
See related
EnsemblRapid:ENSRNOG00000049676 AllianceGenome:RGD:1564252
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat7E; ST6GalNAcV
Summary
Predicted to enable alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Predicted to be involved in ganglioside biosynthetic process and oligosaccharide biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human ST6GALNAC5 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905725.1 and NW_007905726.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]
Expression
Biased expression in Brain (RPKM 56.1), Adrenal (RPKM 4.0) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See St6galnac5 in Genome Data Viewer
Location:
2q45
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (244398604..244571100, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (241741933..241911214, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (258025177..259150709, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100977 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class K Neighboring gene uncharacterized LOC134485772 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats. Okajima T, et al. J Biol Chem, 1999 Oct 22. PMID 10521438
  2. Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. Tsuchida A, et al. J Biol Chem, 2003 Jun 20. PMID 12668675
  3. The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach. Harduin-Lepers A, et al. Glycobiology, 2005 Aug. PMID 15843597
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ganglioside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
Names
GD1 alpha synthase
GalNAc alpha-2,6-sialyltransferase V
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
ST6 GalNAc alpha-2,6-sialyltransferase 5
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase V
sialyltransferase 7E
NP_001258290.1
XP_038958743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271361.2 → NP_001258290.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5

    See identical proteins and their annotated locations for NP_001258290.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A9K3Y7N2, M0R986, Q6ZXY9
    Related
    ENSRNOP00000066049.2, ENSRNOT00000072899.4
    Conserved Domains (1) summary
    pfam00777
    Location:91 → 312
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    244398604..244571100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102815.2 → XP_038958743.1  alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:95 → 276
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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