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Cert1 ceramide transporter 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365652, updated on 14-Nov-2024

Summary

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Official Symbol
Cert1provided by RGD
Official Full Name
ceramide transporter 1provided by RGD
Primary source
RGD:1309131
See related
EnsemblRapid:ENSRNOG00000015686 AllianceGenome:RGD:1309131
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Col4a3bp
Summary
Predicted to enable several functions, including ceramide transfer activity; identical protein binding activity; and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane sphingolipid transfer. Predicted to act upstream of or within several processes, including ceramide metabolic process; in utero embryonic development; and lipid homeostasis. Predicted to be located in several cellular components, including Golgi apparatus; nucleoplasm; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 34. Orthologous to human CERT1 (ceramide transporter 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 192.5), Adrenal (RPKM 183.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cert1 in Genome Data Viewer
Location:
2q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (29617202..29721734)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (27882546..27987090)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (27365145..27469797)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and death domain containing 1B Neighboring gene DNA polymerase kappa Neighboring gene 3-hydroxy-3-methylglutaryl-CoA reductase Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene ankyrin repeat domain 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain. Mencarelli C, et al. J Chem Neuroanat, 2009 Oct. PMID 19555756
  2. Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells. Rao RP, et al. PLoS One, 2014. PMID 24642596, Free PMC Article
  3. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide. Kudo N, et al. Proc Natl Acad Sci U S A, 2008 Jan 15. PMID 18184806, Free PMC Article
  4. Fetal asphyxia induces acute and persisting changes in the ceramide metabolism in rat brain. Vlassaks E, et al. J Lipid Res, 2013 Jul. PMID 23625371, Free PMC Article
  5. Molecular machinery for non-vesicular trafficking of ceramide. Hanada K, et al. Nature, 2003 Dec 18. PMID 14685229

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Levels of GPBP were observed widely throughout the brain, suggesting that GPBP plays an important role in central nervous system neuron function.
    Title: The expression of the Goodpasture antigen-binding protein (ceramide transporter) in adult rat brain.
  2. CERT is a physiological substrate of PP2Cepsilon and that dephosphorylation of CERT by PP2Cepsilon may play an important role in the regulation of ceramide trafficking from the ER to the Golgi apparatus.
    Title: Protein phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ceramide binding ISO
Inferred from Sequence Orthology
more info
  
enables ceramide transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ER to Golgi ceramide transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ER to Golgi ceramide transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane sphingolipid transfer ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitochondrion organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within muscle contraction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ceramide transfer protein
Names
alpha 3 type IV collagen binding protein
collagen type IV alpha 3 binding protein
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
procollagen, type IV, alpha 3 (Goodpasture antigen) binding protein
NP_001102405.1
XP_006231889.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108935.1 → NP_001102405.1  ceramide transfer protein

    See identical proteins and their annotated locations for NP_001102405.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473955
    UniProtKB/TrEMBL
    A6I509, D4ACN6
    Related
    ENSRNOP00000021549.6, ENSRNOT00000021549.7
    Conserved Domains (3) summary
    cd08872
    Location:391 → 624
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:26 → 125
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 114
    PH; PH domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    29617202..29721734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006231827.5 → XP_006231889.1  ceramide transfer protein isoform X1

    See identical proteins and their annotated locations for XP_006231889.1

    UniProtKB/TrEMBL
    A0A8I5ZRB1, A6I510
    Related
    ENSRNOP00000080901.1, ENSRNOT00000110704.2
    Conserved Domains (3) summary
    cd08872
    Location:364 → 598
    START_STARD11-like; Ceramide-binding START domain of mammalian STARD11 and related domains
    cd13283
    Location:26 → 125
    PH_GPBP; Goodpasture antigen binding protein Pleckstrin homology (PH) domain
    pfam00169
    Location:24 → 114
    PH; PH domain
Nucleotide Protein Strain
Heading Accession and Version

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