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NA neuraminidase [ Influenza A virus (A/New York/392/2004(H3N2)) ]

Gene ID: 3655154, updated on 18-Aug-2023

Summary

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Gene symbol
NA
Gene description
neuraminidase
Locus tag
FLUAVH3N2_s6p1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/New York/392/2004(H3N2)) (strain: A/New York/392/2004, serotype: H3N2, nat-host: Homo sapiens)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 6
Sequence:
NC_007368.1 (20..1429)

NC_007368.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007368.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions. Hussain S, et al. J Gen Virol, 2021 Oct. PMID 34596510
  2. Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding. Powell H, et al. PLoS Pathog, 2020 Jun. PMID 32598381, Free PMC Article
  3. [Analysis of the Neuraminidase Amino Acid Sequences of Influenza A/H1N1pdm09, A/H3N2, and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season]. Ikematsu H, et al. Fukuoka Igaku Zasshi, 2015 Aug. PMID 26630841
  4. [Analysis of influenza A/H3N2 neuraminidase genes obtained from influenza patients in the 2011/12 and 2012/13 seasons in Japan]. Ikematsu H, et al. Fukuoka Igaku Zasshi, 2015 Jan. PMID 25942938
  5. A mutant influenza virus that uses an N1 neuraminidase as the receptor-binding protein. Hooper KA, et al. J Virol, 2013 Dec. PMID 24027333, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The genetic characterization of hemagglutinin (HA), neuraminidase (NA) and polymerase acidic (PA) genes of H3N2 influenza viruses circulated in Guangdong Province of China during 2019-2020.
    Title: The genetic characterization of hemagglutinin (HA), neuraminidase (NA) and polymerase acidic (PA) genes of H3N2 influenza viruses circulated in Guangdong Province of China during 2019-2020.
  2. Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions.
    Title: Reduced sialidase activity of influenza A(H3N2) neuraminidase associated with positively charged amino acid substitutions.
  3. Limited Predictability of Amino Acid Substitutions in Seasonal Influenza Viruses.
    Title: Limited Predictability of Amino Acid Substitutions in Seasonal Influenza Viruses.
  4. Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding.
    Title: Neuraminidase antigenic drift of H3N2 clade 3c.2a viruses alters virus replication, enzymatic activity and inhibitory antibody binding.
  5. The viruses harboring the 245-248 deletion in the neuraminidase gene were still present after discontinuation of oseltamivir treatment and passages in cell cultures, indicating a potential risk for transmission of the deleted virus. Deletion in the neuramindase gene of influenza A H3N2 induce antiviral resistance. Influenza A H3N2 virus with antiviral resistance deletion retains fitness.
    Title: Antiviral resistance due to deletion in the neuraminidase gene and defective interfering-like viral polymerase basic 2 RNA of influenza A virus subtype H3N2.
  6. we also demonstrate that NA[neuraminidase] mutations at residue Q136 can confer reduced zanamivir, peramivir or laninamivir susceptibility.
    Title: Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring.
  7. No additional NA amino acid sequences related to the IC50 of the four NA inhibitors was found
    Title: [Analysis of the Neuraminidase Amino Acid Sequences of Influenza A/H1N1pdm09, A/H3N2, and B Viruses Isolated from Influenza Patients in the 2013/14 Japanese Influenza Season].
  8. FLUAV strains can counteract tetherin via their HA and NA proteins identifies these proteins as novel tetherin antagonists and indicates that HA/NA-dependent inactivation of innate defenses may contribute to the efficient spread of pandemic FLUAV.
    Title: Tetherin Sensitivity of Influenza A Viruses Is Strain Specific: Role of Hemagglutinin and Neuraminidase.
  9. One putative amino acid mutation, D151N, was found in an NA activity-related cite in five of ninety-six tested isolate
    Title: [Analysis of influenza A/H3N2 neuraminidase genes obtained from influenza patients in the 2011/12 and 2012/13 seasons in Japan].
  10. G147R mutation enables NA binding to virus receptor in the infected cells.
    Title: A mutant influenza virus that uses an N1 neuraminidase as the receptor-binding protein.
Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Homology

General protein information

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Preferred Names
neuraminidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007368.1 Reference assembly

    Range
    20..1429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_308842.1 neuraminidase [Influenza A virus (A/New York/392/2004(H3N2))]

    See identical proteins and their annotated locations for YP_308842.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A3RMN9, B2BVL1, C3PR29, F6GP71, F8IY01, Q464B6, Q464D8, Q464G0
    Conserved Domains (1) summary
    cd15483
    Location:83 → 466
    Influenza_NA; Sialidase or neuraminidase (EC 3.2.1.18) of Influenza viruses A and B
Nucleotide Protein
Heading Accession and Version

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