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NA neuraminidase [ Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) ]

Gene ID: 3654619, updated on 18-Aug-2023

Summary

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Gene symbol
NA
Gene description
neuraminidase
Locus tag
FLUAVH5N1_s6gp1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) (strain: A/Goose/Guangdong/1/96(H5N1))
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Sequence:
NC_007361.1 (21..1430)

NC_007361.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007361.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel I117T substitution in neuraminidase of highly pathogenic avian influenza H5N1 virus conferring reduced susceptibility to oseltamivir and zanamivir. Kode SS, et al. Vet Microbiol, 2019 Aug. PMID 31282375
  2. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. Ju X, et al. J Virol, 2015 Oct. PMID 26246576, Free PMC Article
  3. The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface. Qian G, et al. Vet J, 2014 Dec. PMID 25458889
  4. Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses. Kalthoff D, et al. J Virol, 2013 Dec. PMID 24109212, Free PMC Article
  5. Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approach. Karthick V, et al. Cell Biochem Biophys, 2014 Mar. PMID 23794010

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Acute myeloid leukaemia marker 1 (AML1) as a novel interacting partner of influenza A H5N1 virus NA protein.
    Title: AML1 protein interacts with influenza A virus neuraminidase and upregulates IFN-β response in infected mammalian cells.
  2. a novel I117T mutation in AI H5N1 virus confers cross-resistance to oseltamivir and zanamivir
    Title: A novel I117T substitution in neuraminidase of highly pathogenic avian influenza H5N1 virus conferring reduced susceptibility to oseltamivir and zanamivir.
  3. Neuraminidase of Influenza A virus binds lysosome-associated membrane proteins directly and induces lysosome rupture.
    Title: Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture.
  4. The results of the study reveal that amino acid residues 7-15 of H5N1 NA are critical for its biosynthetic transport to the host cell surface.
    Title: The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface.
  5. Influenza A Virus, H5N1 Subtype with a R292K NA mutation are highly resistant to the oseltamivir.
    Title: Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approach.
  6. Cysteine deletion in the stalk region is important for the infectivity of A/Anhui/1/05 (H5N1).
    Title: [Virological impact of stalk region of neuraminidase in influenza A/Anhui/1/05 (H5N1) and A/Ohio/07/2009 (H1N1) viruses].
  7. Loss of the neuraminidase protein and enzymatic activity did not affect virus replication efficiency.
    Title: Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses.
  8. Data indicate that recombinant viruses, rPR8-H1N1NA, rPR8-H5N1NA, and rPR8-H9N2NA, were shown to have similar growth kinetics in cells and pathogenicity in mice, but witih differential effects on virus release, and cell-cell fusion.
    Title: NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion.
  9. The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase
    Title: The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase.
  10. highly pathogenic H5N1 variants carrying mutations within the NA active site that decrease susceptibility to NA inhibitors may possess increased virulence in mammalian hosts compared to drug-sensitive viruses
    Title: Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets.
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Homology

General protein information

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Preferred Names
neuraminidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007361.1 Reference assembly

    Range
    21..1430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_308668.1 neuraminidase [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]

    See identical proteins and their annotated locations for YP_308668.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9Q0U7
    UniProtKB/TrEMBL
    Q807U2
    Conserved Domains (1) summary
    cd15483
    Location:85 → 465
    Influenza_NA; Sialidase or neuraminidase (EC 3.2.1.18) of Influenza viruses A and B
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Q0U7.1

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