Reep5 receptor accessory protein 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Reep5provided by RGD
Official Full Name: receptor accessory protein 5provided by RGD
Primary source: RGD:1306047
See related: EnsemblRapid:ENSRNOG00000020167 AllianceGenome:RGD:1306047
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dp1
Summary: Predicted to be involved in endoplasmic reticulum membrane organization. Predicted to be located in endoplasmic reticulum tubular network and junctional sarcoplasmic reticulum membrane. Orthologous to human REEP5 (receptor accessory protein 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 795.8), Brain (RPKM 489.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26219528..26257505, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (25945375..25983271, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27128462..27159693, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

REEP5 modulates cardiac function by shaping the sarcoplasmic reticulum. REEP5 defect deforms the SR architecture to depress cardiac contractility in heart failure.
Title: REEP5 (Receptor Accessory Protein 5) Acts as a Sarcoplasmic Reticulum Membrane Sculptor to Modulate Cardiac Function.

Submit: New GeneRIF Correction

General gene information

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Markers

AI228530 (e-PCR)
- UniSTS:250520

BI279301 (e-PCR)
- UniSTS:244931

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum membrane organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum membrane organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum tubular network	ISS Inferred from Sequence or Structural Similarity more info
located_in junctional sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor expression-enhancing protein 5

Names: deleted in polyposis 1; polyposis locus protein 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108888.2 → NP_001102358.2 receptor expression-enhancing protein 5

See identical proteins and their annotated locations for NP_001102358.2

Status: VALIDATED

Source sequence(s)

AA819308, BC167013, BE126660, BP503102, FM032375

UniProtKB/Swiss-Prot

B2RZ37

UniProtKB/TrEMBL

A0A8I6AL10

Related

ENSRNOP00000027345.6, ENSRNOT00000027345.7

Conserved Domains (1) summary

pfam03134
Location:67 → 144

TB2_DP1_HVA22; TB2/DP1, HVA22 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

26219528..26257505 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097000.2 → XP_038952928.1 receptor expression-enhancing protein 5 isoform X1

Conserved Domains (1) summary

pfam03134
Location:38 → 115

TB2_DP1_HVA22; TB2/DP1, HVA22 family