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Spt-I Serine palmitoyltransferase subunit I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36448, updated on 18-Sep-2024

Summary

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Official Symbol
Spt-Iprovided by FlyBase
Official Full Name
Serine palmitoyltransferase subunit Iprovided by FlyBase
Primary source
FLYBASE:FBgn0086532
Locus tag
Dmel_CG4016
See related
AllianceGenome:FB:FBgn0086532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4016; Dmel\CG4016; dSpt1; l(2)49Fb; l(2)SH1626; l(2)SH2 1626; lcb1; SPT; SPT-I; Spt1; SPT1
Summary
Predicted to enable serine C-palmitoyltransferase activity. Involved in positive regulation of sphingolipid biosynthetic process. Predicted to be part of serine C-palmitoyltransferase complex. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including adult head; central brain primordium; embryonic brain; embryonic/larval midgut; and presumptive embryonic/larval digestive system. Used to study hereditary sensory neuropathy. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1A. Orthologous to human SPTLC1 (serine palmitoyltransferase long chain base subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Spt-I in Genome Data Viewer
Location:
49F4-49F4; 2-68 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13168498..13170744)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9056003..9058249)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Neurospecific receptor kinase Neighboring gene uncharacterized protein Neighboring gene Glial Lazarillo Neighboring gene antisense RNA:CR45142 Neighboring gene 1,4-Alpha-Glucan Branching Enzyme Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Sanchez D, et al. Curr Biol, 2006 Apr 4. PMID 16581513
  2. Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1. Oswald MC, et al. Hum Mol Genet, 2015 Dec 15. PMID 26395456, Free PMC Article
  3. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
  4. Sphingolipid-dependent Dscam sorting regulates axon segregation. Goyal G, et al. Nat Commun, 2019 Feb 18. PMID 30778062, Free PMC Article
  5. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid. Panevska A, et al. Biochim Biophys Acta Biomembr, 2019 Jul 1. PMID 31067435

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine C-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of serine palmitoyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
serine palmitoyltransferase subunit I
Names
CG4016-PA
CG4016-PB
CG4016-PC
Spt-I-PA
Spt-I-PB
Spt-I-PC
lethal (2) SH1626
NP_610842.1
NP_725255.1
NP_725256.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    13168498..13170744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165967.4 → NP_725255.1  serine palmitoyltransferase subunit I, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725255.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR46
    Related
    FBpp0086842
    Conserved Domains (2) summary
    COG0156
    Location:79 → 463
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    cl18945
    Location:22 → 468
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  2. NM_165968.4 → NP_725256.1  serine palmitoyltransferase subunit I, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725256.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR46
    Related
    FBpp0086844
    Conserved Domains (2) summary
    COG0156
    Location:79 → 463
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    cl18945
    Location:22 → 468
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

  3. NM_136998.2 → NP_610842.1  serine palmitoyltransferase subunit I, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NR46
    Related
    FBpp0086843
    Conserved Domains (2) summary
    COG0156
    Location:79 → 463
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    cl18945
    Location:22 → 468
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NR46 Q6NR46

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