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Cideb cell death-inducing DFFA-like effector b [ Rattus norvegicus (Norway rat) ]

Gene ID: 364388, updated on 2-Nov-2024

Summary

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Official Symbol
Cidebprovided by RGD
Official Full Name
cell death-inducing DFFA-like effector bprovided by RGD
Primary source
RGD:1310000
See related
EnsemblRapid:ENSRNOG00000020377 AllianceGenome:RGD:1310000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including identical protein binding activity; lipid transfer activity; and phosphatidic acid binding activity. Involved in response to nutrient levels. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat. Predicted to be active in Golgi apparatus; endoplasmic reticulum membrane; and lipid droplet. Orthologous to human CIDEB (cell death inducing DFFA like effector b). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 442.3) and Kidney (RPKM 155.4) See more
Orthologs
human mouse all
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Genomic context

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See Cideb in Genome Data Viewer
Location:
15p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (33222135..33226407, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (29252208..29256482, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (34439844..34444244, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 2 Neighboring gene dehydrogenase/reductase 1 Neighboring gene NOP9 nucleolar protein Neighboring gene leukotriene B4 receptor 2 Neighboring gene leukotriene B4 receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle. Tiwari S, et al. J Biol Chem, 2013 Feb 15. PMID 23297397, Free PMC Article
  2. The hepatitis C virus NS2 protein is an inhibitor of CIDE-B-induced apoptosis. Erdtmann L, et al. J Biol Chem, 2003 May 16. PMID 12595532
  3. Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. Liang L, et al. Biochem J, 2003 Feb 15. PMID 12429024, Free PMC Article
  4. Impaired VLDL assembly: a novel mechanism contributing to hepatic lipid accumulation following ovariectomy and high-fat/high-cholesterol diets? Côté I, et al. Br J Nutr, 2014 Nov 28. PMID 25263431
  5. CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. Inohara N, et al. EMBO J, 1998 May 1. PMID 9564035, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle
    Title: CideB protein is required for the biogenesis of very low density lipoprotein (VLDL) transport vesicle.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid transfer activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid droplet fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to nutrient levels IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in very-low-density lipoprotein particle assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lipid transferase CIDEB
Names
cell death activator CIDE-B
cell death-inducing DNA fragmentation factor, alpha subunit-like effector B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399449.1 → NP_001386378.1  lipid transferase CIDEB

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    Related
    ENSRNOP00000027612.5, ENSRNOT00000027612.8
    Conserved Domains (1) summary
    cd06537
    Location:34 → 114
    CIDE_N_B; CIDE_N domain of CIDE-B proteins. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins. These proteins are associated with the chromatin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    33222135..33226407 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108869.2: Suppressed sequence

    Description
    NM_001108869.2: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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