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Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 363113, updated on 2-Nov-2024

Summary

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Symbol
Syncripprovided by RGD
Full Name
synaptotagmin binding, cytoplasmic RNA interacting proteinprovided by RGD
Primary source
RGD:1305683
See related
EnsemblRapid:ENSRNOG00000000204 AllianceGenome:RGD:1305683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ab2-339; hnRNP Q
Summary
Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in circadian rhythm; negative regulation of mRNA modification; and positive regulation of translation. Located in neuronal cell body and proximal dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 303.0), Spleen (RPKM 256.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Syncrip in Genome Data Viewer
Location:
8q31
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (98282358..98315412, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89402487..89435517, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (96100692..96266342, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 14 Neighboring gene 5' nucleotidase, ecto Neighboring gene myosin light polypeptide 6-like Neighboring gene small nucleolar RNA SNORD50 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 2 Neighboring gene zinc finger protein 949 Neighboring gene tripartite motif-containing 43A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in the rat brain and co-localize in Purkinje neurons. Tratnjek L, et al. J Chem Neuroanat, 2017 Jan. PMID 27771350
  2. An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites. Bannai H, et al. J Biol Chem, 2004 Dec 17. PMID 15475564
  3. Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production. Kim TD, et al. Genes Dev, 2007 Apr 1. PMID 17403780, Free PMC Article
  4. hnRNP Q regulates Cdc42-mediated neuronal morphogenesis. Chen HH, et al. Mol Cell Biol, 2012 Jun. PMID 22493061, Free PMC Article
  5. Autophagy negatively regulates early axon growth in cortical neurons. Ban BK, et al. Mol Cell Biol, 2013 Oct. PMID 23918799, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Both SYNCRIP (and SYT7) were expressed and partially co-localized in somata of Purkinje neurons in the cerebellar cortex.
    Title: Synaptotagmin 7 and SYNCRIP proteins are ubiquitously expressed in the rat brain and co-localize in Purkinje neurons.
  2. Data indicate that atg7, RhoA and hnRNP-Q1 are involved in autophagy negatively regulates early axon growth in cortical neurons.
    Title: Autophagy negatively regulates early axon growth in cortical neurons.
  3. hnRNP Q1 may participate in localization of mRNAs encoding Cdc42 signaling factors in neurites, and thereby may regulate actin dynamics and control neuronal morphogenesis
    Title: hnRNP Q regulates Cdc42-mediated neuronal morphogenesis.
  4. These data suggest that the PRMT1-mediated methylation of hnRNPQ is implicated in insulin receptor trafficking and insulin signaling in skeletal L6 myotubes.
    Title: Involvement of PRMT1 in hnRNPQ activation and internalization of insulin receptor.
  5. SYNCRIP is transported within the dendrite as a component of mRNA granules
    Title: An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CRD-mediated mRNA stabilization IEA
Inferred from Electronic Annotation
more info
  
involved_in CRD-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytoplasmic translation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CRD-mediated mRNA stability complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CRD-mediated mRNA stability complex IEA
Inferred from Electronic Annotation
more info
  
part_of CRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  
part_of CRD-mediated mRNA stability complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of GAIT complex IEA
Inferred from Electronic Annotation
more info
  
part_of GAIT complex ISO
Inferred from Sequence Orthology
more info
  
part_of catalytic step 2 spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone pre-mRNA 3'end processing complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone pre-mRNA 3'end processing complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of mCRD-mediated mRNA stability complex IEA
Inferred from Electronic Annotation
more info
  
part_of mCRD-mediated mRNA stability complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein Q
Names
hnRNP-Q
liver regeneration-related protein LRRG077

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001047916.3 → NP_001041381.1  heterogeneous nuclear ribonucleoprotein Q isoform 1

    See identical proteins and their annotated locations for NP_001041381.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q7TP47
    UniProtKB/TrEMBL
    A0A8I5ZZ72
    Related
    ENSRNOP00000048433.4, ENSRNOT00000041655.6
    Conserved Domains (4) summary
    cd12483
    Location:71 → 149
    RRM1_hnRNPQ; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
    cd12489
    Location:151 → 235
    RRM2_hnRNPQ; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
    cd12494
    Location:247 → 318
    RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
    TIGR01648
    Location:50 → 525
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  2. NM_001395649.1 → NP_001382578.1  heterogeneous nuclear ribonucleoprotein Q isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K9J1, A0A8I5ZZ72
    Related
    ENSRNOP00000075015.2, ENSRNOT00000078891.3
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 557
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cd21066
    Location:23 → 107
    NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

  3. NM_001395650.1 → NP_001382579.1  heterogeneous nuclear ribonucleoprotein Q isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZZ72
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 553
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cd21066
    Location:23 → 107
    NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

  4. NM_001395651.1 → NP_001382580.1  heterogeneous nuclear ribonucleoprotein Q isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    M0R735
    Related
    ENSRNOP00000065252.3, ENSRNOT00000074515.4
    Conserved Domains (2) summary
    TIGR01648
    Location:103 → 615
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cd21066
    Location:23 → 107
    NURR_hnRNPQ; NURR (N-terminal unit for RNA recognition) domain found in heterogeneous nuclear ribonucleoprotein Q (hnRNPQ) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    98282358..98315412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265796.1 → XP_063121866.1  heterogeneous nuclear ribonucleoprotein Q isoform X2

  2. XM_063265795.1 → XP_063121865.1  heterogeneous nuclear ribonucleoprotein Q isoform X1

  3. XM_063265799.1 → XP_063121869.1  heterogeneous nuclear ribonucleoprotein Q isoform X6

  4. XM_006243514.4 → XP_006243576.1  heterogeneous nuclear ribonucleoprotein Q isoform X3

    UniProtKB/TrEMBL
    M0R735
    Conserved Domains (3) summary
    cd12495
    Location:291 → 362
    RRM3_hnRNPQ; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
    TIGR01648
    Location:103 → 569
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    cl17169
    Location:161 → 222
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_006243518.5 → XP_006243580.1  heterogeneous nuclear ribonucleoprotein Q isoform X4

    Conserved Domains (4) summary
    cd12483
    Location:63 → 141
    RRM1_hnRNPQ; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
    cd12489
    Location:143 → 227
    RRM2_hnRNPQ; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein Q (hnRNP Q)
    cd12494
    Location:239 → 310
    RRM3_hnRNPR; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein R (hnRNP R)
    TIGR01648
    Location:5 → 517
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

  6. XM_063265798.1 → XP_063121868.1  heterogeneous nuclear ribonucleoprotein Q isoform X5

  7. XM_039081769.2 → XP_038937697.1  heterogeneous nuclear ribonucleoprotein Q isoform X7

    Conserved Domains (1) summary
    TIGR01648
    Location:1 → 309
    hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TP47.1 GenPept UniProtKB/Swiss-Prot:Q7TP47

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