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Trmt5 tRNA methyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362754, updated on 2-Nov-2024

Summary

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Official Symbol
Trmt5provided by RGD
Official Full Name
tRNA methyltransferase 5provided by RGD
Primary source
RGD:1306567
See related
EnsemblRapid:ENSRNOG00000007785 AllianceGenome:RGD:1306567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1306567
Summary
Predicted to enable tRNA methyltransferase activity. Predicted to be involved in mitochondrial tRNA methylation and tRNA N1-guanine methylation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 26. Orthologous to human TRMT5 (tRNA methyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 68.7), Spleen (RPKM 55.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Trmt5 in Genome Data Viewer
Location:
6q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97702375..97723534, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91963558..91987660, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96164579..96171680, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene solute carrier family 38, member 6 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies. Powell CA, et al. Am J Hum Genet, 2015 Aug 6. PMID 26189817, Free PMC Article
  2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA N1-guanine methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (guanine(37)-N1)-methyltransferase
Names
TRM5 tRNA methyltransferase 5 homolog
tRNA (guanine-N(1)-)-methyltransferase
tRNA methyltransferase 5 homolog
NP_001383002.1
NP_001383003.1
XP_038968435.1
XP_038968437.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396073.1 → NP_001383002.1  tRNA (guanine(37)-N1)-methyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HC55, F1LYK6
    Conserved Domains (1) summary
    COG2520
    Location:86 → 461
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

  2. NM_001396074.1 → NP_001383003.1  tRNA (guanine(37)-N1)-methyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A6HC56, F1LYK6
    Related
    ENSRNOP00000010546.7, ENSRNOT00000010546.9
    Conserved Domains (1) summary
    COG2520
    Location:35 → 410
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    97702375..97723534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112507.2 → XP_038968435.1  tRNA (guanine(37)-N1)-methyltransferase isoform X1

    UniProtKB/TrEMBL
    A0A0G2JU45, A0A8I5ZMD1
    Related
    ENSRNOP00000068961.1, ENSRNOT00000078190.3
    Conserved Domains (1) summary
    COG2520
    Location:86 → 461
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]

  2. XM_039112509.2 → XP_038968437.1  tRNA (guanine(37)-N1)-methyltransferase isoform X2

    Conserved Domains (1) summary
    COG2520
    Location:1 → 244
    Trm5; tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version

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