Ctrc chymotrypsin C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctrcprovided by RGD
Official Full Name: chymotrypsin Cprovided by RGD
Primary source: RGD:1308379
See related: EnsemblRapid:ENSRNOG00000013745 AllianceGenome:RGD:1308379
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within intracellular calcium ion homeostasis. Orthologous to human CTRC (chymotrypsin C). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
Expression: Biased expression in Spleen (RPKM 2053.4) and Liver (RPKM 472.7) See more
Orthologs: human all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (159430333..159439557, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (154147314..154156540, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (160394677..160403373, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

possibly involved in enamel development
Title: Chymotrypsin C (caldecrin) is associated with enamel development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chymotrypsin-C

Names: caldecrin; preprocaldecrin; serum calcium-decreasing factor

NP_001071117.1

EC 3.4.21.2

XP_063144153.1

EC 3.4.21.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077649.2 → NP_001071117.1 chymotrypsin-C precursor

See identical proteins and their annotated locations for NP_001071117.1

Status: PROVISIONAL

Source sequence(s)

S80379

UniProtKB/Swiss-Prot

P55091, Q63188

UniProtKB/TrEMBL

A0A8L2Q952, A6ITX2

Related

ENSRNOP00000018393.5, ENSRNOT00000018393.7

Conserved Domains (2) summary

smart00020
Location:29 → 262

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:30 → 265

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...