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Tle1 TLE family member 1, transcriptional corepressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 362533, updated on 2-Nov-2024

Summary

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Official Symbol
Tle1provided by RGD
Official Full Name
TLE family member 1, transcriptional corepressorprovided by RGD
Primary source
RGD:1309237
See related
EnsemblRapid:ENSRNOG00000005882 AllianceGenome:RGD:1309237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including chromatin binding activity; identical protein binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Orthologous to human TLE1 (TLE family member 1, transcriptional corepressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 70.6), Lung (RPKM 58.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Tle1 in Genome Data Viewer
Location:
5q31
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (90898182..90982118, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (85851827..85934806, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (88546607..88630277, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene zinc finger protein 101 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons. Stewart L, et al. Brain Res Mol Brain Res, 2005 Oct 31. PMID 16081186
  2. GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR. Xue L, et al. Mol Biol Rep, 2023 Nov. PMID 37819496, Free PMC Article
  3. Characterization of a novel mammalian Groucho isoform and its role in transcriptional regulation. Lepourcelet M, et al. J Biol Chem, 2002 Dec 6. PMID 12359720
  4. Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. Grbavec D, et al. Biochem Biophys Res Commun, 1996 Jun 25. PMID 8687460
  5. Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival. Dastidar SG, et al. J Biol Chem, 2012 Apr 27. PMID 22354967, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
    Title: GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
  2. TLE1 cooperates with FoxG1 to promote neuronal survival in a CK2- and PI3K-Akt-dependent manner.
    Title: Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival.
  3. TLE1 expression was mostly localized to neurons and occurs in mature cortical and cerebellar neurons.
    Title: Dendritic localization of the transcriptional co-repressor Groucho/TLE1 in cortical and cerebellar neurons.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189561

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transducin-like enhancer protein 1
Names
transducin like enhancer of split 1
transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173433.1 → NP_001166904.1  transducin-like enhancer protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D3ZCM7
    Related
    ENSRNOP00000055692.4, ENSRNOT00000058906.5
    Conserved Domains (3) summary
    cd00200
    Location:483 → 767
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:487 → 526
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    90898182..90982118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017593478.3 → XP_017448967.1  transducin-like enhancer protein 1 isoform X12

    UniProtKB/TrEMBL
    D3ZCM7
    Related
    ENSRNOP00000095904.2, ENSRNOT00000098507.2
    Conserved Domains (4) summary
    PHA03378
    Location:231 → 393
    PHA03378; EBNA-3B; Provisional
    cd00200
    Location:409 → 693
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:413 → 452
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 128
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  2. XM_039110257.2 → XP_038966185.1  transducin-like enhancer protein 1 isoform X10

    UniProtKB/TrEMBL
    D3ZCM7

  3. XM_006238293.5 → XP_006238355.1  transducin-like enhancer protein 1 isoform X13

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:481 → 765
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:485 → 524
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  4. XM_006238288.5 → XP_006238350.1  transducin-like enhancer protein 1 isoform X8

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  5. XM_006238284.5 → XP_006238346.1  transducin-like enhancer protein 1 isoform X4

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:516 → 800
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:520 → 559
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 132
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  6. XM_006238287.5 → XP_006238349.1  transducin-like enhancer protein 1 isoform X7

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:482 → 766
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:486 → 525
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  7. XM_006238283.5 → XP_006238345.1  transducin-like enhancer protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AT29, D3ZCM7
    Related
    ENSRNOP00000097506.1, ENSRNOT00000102954.2
    Conserved Domains (3) summary
    cd00200
    Location:517 → 801
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:521 → 560
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 133
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  8. XM_008763786.4 → XP_008762008.2  transducin-like enhancer protein 1 isoform X2

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:526 → 810
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:530 → 569
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 142
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  9. XM_006238286.5 → XP_006238348.1  transducin-like enhancer protein 1 isoform X6

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:492 → 776
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:496 → 535
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  10. XM_017593476.3 → XP_017448965.1  transducin-like enhancer protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A8I5, D3ZCM7
    Related
    ENSRNOP00000088662.1, ENSRNOT00000116062.2
    Conserved Domains (3) summary
    cd00200
    Location:493 → 777
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:497 → 536
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  11. XM_006238281.5 → XP_006238343.1  transducin-like enhancer protein 1 isoform X1

    UniProtKB/TrEMBL
    D3ZCM7
    Conserved Domains (3) summary
    cd00200
    Location:527 → 811
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:531 → 570
    7WD40; WD40 repeat [structural motif]
    pfam03920
    Location:9 → 143
    TLE_N; Groucho/TLE N-terminal Q-rich domain

  12. XM_006238289.4 → XP_006238351.1  transducin-like enhancer protein 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2K324
    Related
    ENSRNOP00000072474.1, ENSRNOT00000089560.3
    Conserved Domains (4) summary
    COG2319
    Location:468 → 760
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:475 → 759
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam03920
    Location:27 → 91
    TLE_N; Groucho/TLE N-terminal Q-rich domain
    sd00039
    Location:479 → 518
    7WD40; WD40 repeat [structural motif]

  13. XM_008763792.3 → XP_008762014.1  transducin-like enhancer protein 1 isoform X11

    See identical proteins and their annotated locations for XP_008762014.1

    UniProtKB/TrEMBL
    A0A0G2K324
    Conserved Domains (3) summary
    COG2319
    Location:405 → 697
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:412 → 696
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:416 → 455
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
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