Lpcat3 lysophosphatidylcholine acyltransferase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lpcat3provided by RGD
Official Full Name: lysophosphatidylcholine acyltransferase 3provided by RGD
Primary source: RGD:1310223
See related: EnsemblRapid:ENSRNOG00000012269 AllianceGenome:RGD:1310223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oact5; Grcc3f; Mboat5
Summary: Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be involved in several processes, including glycerophospholipid metabolic process; plasma lipoprotein particle assembly; and positive regulation of lipid transport. Predicted to act upstream of or within regulation of plasma lipoprotein particle levels. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 364.2), Kidney (RPKM 331.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (159154690..159196176)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (157468397..157509889)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (157181722..157222997)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPCAT3 exacerbates early brain injury and ferroptosis after subarachnoid hemorrhage in rats.
Title: LPCAT3 exacerbates early brain injury and ferroptosis after subarachnoid hemorrhage in rats.
PTG has a role in phosphorylase kinase inactivation and glycogen synthase translocation
Title: The glycogenic action of protein targeting to glycogen in hepatocytes involves multiple mechanisms including phosphorylase inactivation and glycogen synthase translocation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH143230 (e-PCR)
- UniSTS:232477

RH140386 (e-PCR)
- UniSTS:222462

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphocholine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipid acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in chylomicron assembly	ISO Inferred from Sequence Orthology more info
involved_in chylomicron assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum membrane organization	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum membrane organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in intestinal stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intestinal stem cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of response to endoplasmic reticulum stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intestinal cholesterol absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of triglyceride transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of plasma lipoprotein particle levels	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in very-low-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lysophospholipid acyltransferase 5

Names: 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; LPLAT 5; O-acyltransferase (membrane bound) domain containing 5; O-acyltransferase domain-containing protein 5; gene rich cluster, C3f; lyso-PC acyltransferase 3; membrane bound O-acyltransferase domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5

NP_001012189.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_063142422.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.