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Reep1 receptor accessory protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362384, updated on 17-Aug-2024

Summary

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Official Symbol
Reep1provided by RGD
Official Full Name
receptor accessory protein 1provided by RGD
Primary source
RGD:1305230
See related
EnsemblRapid:ENSRNOG00000008481 AllianceGenome:RGD:1305230
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305230
Summary
Predicted to enable microtubule binding activity and olfactory receptor binding activity. Predicted to be involved in endoplasmic reticulum tubular network organization; protein insertion into membrane; and regulation of intracellular transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 5B and hereditary spastic paraplegia 31. Orthologous to human REEP1 (receptor accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 195.5), Muscle (RPKM 195.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Reep1 in Genome Data Viewer
Location:
4q32
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105303974..105420611)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103746004..103862347)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99618622..99735329)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 3 Neighboring gene lysine demethylase 3A Neighboring gene uncharacterized LOC134486590 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene inner membrane mitochondrial protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network. Park SH, et al. J Clin Invest, 2010 Apr. PMID 20200447, Free PMC Article
  2. REEPs are membrane shaping adapter proteins that modulate specific g protein-coupled receptor trafficking by affecting ER cargo capacity. Björk S, et al. PLoS One, 2013. PMID 24098485, Free PMC Article
  3. Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia. Hashimoto Y, et al. J Biol Chem, 2014 May 9. PMID 24668814, Free PMC Article
  4. RTP family members induce functional expression of mammalian odorant receptors. Saito H, et al. Cell, 2004 Nov 24. PMID 15550249
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables olfactory receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network organization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein insertion into membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of intracellular transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum tubular network ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor expression-enhancing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108633.2 → NP_001102103.1  receptor expression-enhancing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001102103.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IA87
    Related
    ENSRNOP00000104154.1, ENSRNOT00000139860.1
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  2. NM_001429156.1 → NP_001416085.1  receptor expression-enhancing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D4A193

  3. NM_001429157.1 → NP_001416086.1  receptor expression-enhancing protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A8I5ZTG4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    105303974..105420611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286282.1 → XP_063142352.1  receptor expression-enhancing protein 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AD43
    Related
    ENSRNOP00000090724.1, ENSRNOT00000111989.2

  2. XM_039107814.2 → XP_038963742.1  receptor expression-enhancing protein 1 isoform X8

    Related
    ENSRNOP00000087200.2, ENSRNOT00000095632.2
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  3. XM_039107807.2 → XP_038963735.1  receptor expression-enhancing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03134
    Location:28 → 103
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  4. XM_039107810.2 → XP_038963738.1  receptor expression-enhancing protein 1 isoform X4

    Conserved Domains (1) summary
    pfam03134
    Location:1 → 56
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  5. XM_039107812.2 → XP_038963740.1  receptor expression-enhancing protein 1 isoform X5

    Conserved Domains (1) summary
    pfam03134
    Location:28 → 103
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  6. XM_039107809.1 → XP_038963737.1  receptor expression-enhancing protein 1 isoform X2

    Conserved Domains (1) summary
    pfam03134
    Location:28 → 103
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  7. XM_008762992.3 → XP_008761214.1  receptor expression-enhancing protein 1 isoform X3

    Related
    ENSRNOP00000061062.2, ENSRNOT00000064772.3
    Conserved Domains (1) summary
    pfam03134
    Location:19 → 94
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

  8. XM_039107813.2 → XP_038963741.1  receptor expression-enhancing protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GDV4
    Related
    ENSRNOP00000085476.1, ENSRNOT00000095813.2
    Conserved Domains (1) summary
    pfam03134
    Location:28 → 103
    TB2_DP1_HVA22; TB2/DP1, HVA22 family

RNA

  1. XR_005503256.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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