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Tspan12 tetraspanin 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362326, updated on 2-Nov-2024

Summary

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Official Symbol
Tspan12provided by RGD
Official Full Name
tetraspanin 12provided by RGD
Primary source
RGD:1311102
See related
EnsemblRapid:ENSRNOG00000059016 AllianceGenome:RGD:1311102
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tm4sf12
Summary
Predicted to be involved in cell surface receptor signaling pathway; regulation of angiogenesis; and retina layer formation. Predicted to act upstream of or within Norrin signaling pathway and maintenance of blood-brain barrier. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 5. Orthologous to human TSPAN12 (tetraspanin 12). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 331.3), Lung (RPKM 278.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan12 in Genome Data Viewer
Location:
4q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (51279562..51355030, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (50313768..50389246, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (48852823..48953240, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily D member 2 Neighboring gene tubulin beta chain-like Neighboring gene uncharacterized LOC134486737 Neighboring gene cytochrome c oxidase subunit 6C-2-like Neighboring gene inhibitor of growth family, member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling. Junge HJ, et al. Cell, 2009 Oct 16. PMID 19837033
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109305

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables Wnt receptor activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables Wnt receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Norrin signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cell surface receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in retina layer formation ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tetraspanin-12
Names
transmembrane 4 superfamily member 12
tspan-12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015026.1 → NP_001015026.1  tetraspanin-12

    See identical proteins and their annotated locations for NP_001015026.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092623
    UniProtKB/Swiss-Prot
    Q569A2
    UniProtKB/TrEMBL
    A0A8I6GLC8
    Related
    ENSRNOP00000072130.1, ENSRNOT00000083938.3
    Conserved Domains (2) summary
    cd03157
    Location:116 → 218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 244
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    51279562..51355030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762788.4 → XP_008761010.1  tetraspanin-12 isoform X1

    See identical proteins and their annotated locations for XP_008761010.1

    UniProtKB/Swiss-Prot
    Q569A2
    UniProtKB/TrEMBL
    A0A8I6GLC8
    Conserved Domains (2) summary
    cd03157
    Location:116 → 218
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:10 → 244
    Tetraspannin; Tetraspanin family

  2. XM_039107771.2 → XP_038963699.1  tetraspanin-12 isoform X4

    Conserved Domains (1) summary
    cd03157
    Location:1 → 99
    TM4SF12_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF12_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

  3. XM_008762790.3 → XP_008761012.1  tetraspanin-12 isoform X3

    Conserved Domains (2) summary
    cl02781
    Location:116 → 206
    tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
    pfam00335
    Location:9 → 194
    Tetraspannin; Tetraspanin family

  4. XM_017592685.3 → XP_017448174.1  tetraspanin-12 isoform X2

  5. XM_063286235.1 → XP_063142305.1  tetraspanin-12 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q569A2.1 GenPept UniProtKB/Swiss-Prot:Q569A2

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