U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Osbpl5 oxysterol binding protein-like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361686, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Osbpl5provided by RGD
Official Full Name
oxysterol binding protein-like 5provided by RGD
Primary source
RGD:1308402
See related
EnsemblRapid:ENSRNOG00000020713 AllianceGenome:RGD:1308402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site and intracellular membrane-bounded organelle. Predicted to be active in cytosol and membrane. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 118.3), Kidney (RPKM 62.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Osbpl5 in Genome Data Viewer
Location:
1q42
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208291441..208362086, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198862071..198916469, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216866263..216920625, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 26 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene MAS related GPR family member G like 1 Neighboring gene MAS related GPR family member G

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Chung J, et al. Science, 2015 Jul 24. PMID 26206935, Free PMC Article
  2. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda K, et al. Nature, 2013 Sep 12. PMID 23934110
  3. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
  4. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC109308

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine transfer activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
oxysterol-binding protein-related protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015024.2 → NP_001015024.2  oxysterol-binding protein-related protein 5

    See identical proteins and their annotated locations for NP_001015024.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2JV78, A6HYD0, G3V8S8
    Related
    ENSRNOP00000028119.5, ENSRNOT00000028119.7
    Conserved Domains (3) summary
    cd13286
    Location:144 → 272
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:151 → 267
    PH; PH domain
    pfam01237
    Location:397 → 732
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    208291441..208362086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268111.1 → XP_063124181.1  oxysterol-binding protein-related protein 5 isoform X1

    Related
    ENSRNOP00000082076.2, ENSRNOT00000100959.2

  2. XM_006230828.5 → XP_006230890.1  oxysterol-binding protein-related protein 5 isoform X2

    See identical proteins and their annotated locations for XP_006230890.1

    UniProtKB/TrEMBL
    A0A0G2JV78, A6HYD1
    Conserved Domains (3) summary
    cd13286
    Location:120 → 248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:127 → 243
    PH; PH domain
    pfam01237
    Location:373 → 708
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_006230830.5 → XP_006230892.1  oxysterol-binding protein-related protein 5 isoform X2

    See identical proteins and their annotated locations for XP_006230892.1

    UniProtKB/TrEMBL
    A0A0G2JV78, A6HYD1
    Conserved Domains (3) summary
    cd13286
    Location:120 → 248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:127 → 243
    PH; PH domain
    pfam01237
    Location:373 → 708
    Oxysterol_BP; Oxysterol-binding protein

  4. XM_039083625.2 → XP_038939553.1  oxysterol-binding protein-related protein 5 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JV78
    Related
    ENSRNOP00000112749.1, ENSRNOT00000139372.1
    Conserved Domains (2) summary
    cd13286
    Location:49 → 177
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:302 → 644
    Oxysterol_BP; Oxysterol-binding protein

  5. XM_006230829.5 → XP_006230891.1  oxysterol-binding protein-related protein 5 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZYG1
    Conserved Domains (3) summary
    cd13286
    Location:120 → 248
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:127 → 243
    PH; PH domain
    pfam01237
    Location:373 → 708
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools