Stim1 stromal interaction molecule 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stim1provided by RGD
Official Full Name: stromal interaction molecule 1provided by RGD
Primary source: RGD:1306831
See related: EnsemblRapid:ENSRNOG00000020425 AllianceGenome:RGD:1306831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium channel regulator activity and store-operated calcium channel activity. Involved in activation of store-operated calcium channel activity; regulation of store-operated calcium entry; and store-operated calcium entry. Located in growth cone. Used to study nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in Stormorken syndrome; gastrointestinal system cancer (multiple); immunodeficiency 10; lung cancer; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 263.7), Thymus (RPKM 179.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (166067450..166230733)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (156656246..156818777)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (167373894..167533412)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Role and Mechanism of STIM1/Orai1-Regulated Ca[2+] Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Title: The Role and Mechanism of STIM1/Orai1-Regulated Ca(2+) Influx in Myocardial Hypertrophy in Type 2 Diabetes Mellitus.
Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat.
Title: Genotypes of Stim1 and the proximal region on chromosome 1 exert opposite effects on stroke susceptibility in stroke-prone spontaneously hypertensive rat.
Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
Title: Na(+)/Ca(2+) exchanger isoform 1 (NCX1) and canonical transient receptor potential channel 6 (TRPC6) are recruited by STIM1 to mediate Store-Operated Calcium Entry in primary cortical neurons.
STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
Title: STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats.
Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation.
Title: Mapping the Proximity Interaction Network of STIM1 Reveals New Mechanisms of Cytoskeletal Regulation.
Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Title: Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension.
Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning.
Title: Lysosomal calcium is modulated by STIM1/TRPML1 interaction which participates to neuronal survival during ischemic preconditioning.
Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat.
Title: Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat.
Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9.
Title: Pathophysiological significance of Stim1 mutation in sympathetic response to stress and cardiovascular phenotypes in SHRSP/Izm: In vivo evaluation by creation of a novel gene knock-in rat using CRISPR/Cas9.
STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.
Title: STIM Protein-NMDA2 Receptor Interaction Decreases NMDA-Dependent Calcium Levels in Cortical Neurons.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Rat51 (e-PCR), detects polymorphism
- UniSTS:118592

AU048526 (e-PCR)
- UniSTS:144976

Stim1 (e-PCR), detects polymorphism
- UniSTS:144516

MGI:1276896 (e-PCR)
- UniSTS:144517

D1Mgh34 (e-PCR)
- UniSTS:239288

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel regulator activity	IEA Inferred from Electronic Annotation more info
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calcium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables channel activator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule plus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule plus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of store-operated calcium channel activity	IEA Inferred from Electronic Annotation more info
involved_in activation of store-operated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in activation of store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
involved_in activation of store-operated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in detection of calcium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in enamel mineralization	ISO Inferred from Sequence Orthology more info
involved_in enamel mineralization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ligand-gated ion channel signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in regulation of store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info
involved_in store-operated calcium entry	IBA Inferred from Biological aspect of Ancestor more info
involved_in store-operated calcium entry	IDA Inferred from Direct Assay more info	PubMed
involved_in store-operated calcium entry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info
involved_in store-operated calcium entry	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stromal interaction molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108496.2 → NP_001101966.2 stromal interaction molecule 1 precursor

See identical proteins and their annotated locations for NP_001101966.2

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/Swiss-Prot

P84903

UniProtKB/TrEMBL

A6I737

Conserved Domains (3) summary

cd09573
Location:128 → 201

SAM_STIM1; SAM domain of STIM1 subfamily proteins

COG1196
Location:237 → 434

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam16533
Location:344 → 441

SOAR; STIM1 Orai1-activating region