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Me3 malic enzyme 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361602, updated on 19-Sep-2024

Summary

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Official Symbol
Me3provided by RGD
Official Full Name
malic enzyme 3provided by RGD
Primary source
RGD:1311070
See related
EnsemblRapid:ENSRNOG00000017311 AllianceGenome:RGD:1311070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrion. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 212.8), Muscle (RPKM 105.6) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Me3 in Genome Data Viewer
Location:
1q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152946595..153148026)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143534024..143735551)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (153861535..154058608)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2 Neighboring gene uncharacterized LOC103691188 Neighboring gene serine protease 23 Neighboring gene uncharacterized LOC102549783 Neighboring gene uncharacterized LOC120099878 Neighboring gene coiled-coil domain containing 81 Neighboring gene uncharacterized LOC134483752

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells. Hasan NM, et al. Mol Endocrinol, 2015 Mar. PMID 25594249, Free PMC Article
  2. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Loeber G, et al. Biochem J, 1994 Dec 15. PMID 7818469, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data suggest that ME3, far more than ME1 or ME2, is necessary for insulin release.
    Title: Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding ISO
Inferred from Sequence Orthology
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables malic enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
NADP-dependent malic enzyme, mitochondrial
Names
malic enzyme 3, NADP(+)-dependent, mitochondrial
mitochondrial malic enzyme 3
NP_001402901.1
XP_006229728.1
XP_063123049.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415972.1 → NP_001402901.1  NADP-dependent malic enzyme, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6AK15, F1M5N4
    Related
    ENSRNOP00000089037.1, ENSRNOT00000095307.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    152946595..153148026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006229666.4 → XP_006229728.1  NADP-dependent malic enzyme, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4C6, F1M5N4
    Related
    ENSRNOP00000023329.7, ENSRNOT00000023329.9
    Conserved Domains (3) summary
    cd05312
    Location:305 → 549
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:9 → 554
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:114 → 295
    malic; Malic enzyme, N-terminal domain

  2. XM_063266979.1 → XP_063123049.1  NADP-dependent malic enzyme, mitochondrial isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108491.2: Suppressed sequence

    Description
    NM_001108491.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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