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Mppe1 metallophosphoesterase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361344, updated on 17-Aug-2024

Summary

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Official Symbol
Mppe1provided by RGD
Official Full Name
metallophosphoesterase 1provided by RGD
Primary source
RGD:1309184
See related
EnsemblRapid:ENSRNOG00000018648 AllianceGenome:RGD:1309184
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GPI anchor binding activity; GPI-mannose ethanolamine phosphate phosphodiesterase activity; and manganese ion binding activity. Predicted to be involved in GPI anchor biosynthetic process and endoplasmic reticulum to Golgi vesicle-mediated transport. Predicted to be located in several cellular components, including cis-Golgi network; endoplasmic reticulum exit site; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 57.3), Heart (RPKM 51.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mppe1 in Genome Data Viewer
Location:
18q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63033329..63051461, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (60763418..60781553, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (62946952..62966174, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene G protein subunit alpha L Neighboring gene uncharacterized LOC120098242 Neighboring gene charged multivesicular body protein 1B Neighboring gene uncharacterized LOC120098339 Neighboring gene inositol monophosphatase 2 Neighboring gene uncharacterized LOC134483046

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GPI anchor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GPI-mannose ethanolamine phosphate phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables manganese ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cis-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum exit site ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metallophosphoesterase 1
Names
post-GPI attachment to proteins factor 5
NP_001101905.1
XP_006254941.1
XP_006254943.1
XP_017456488.1
XP_038952909.1
XP_038952910.1
XP_038952911.1
XP_063133553.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108435.2 → NP_001101905.1  metallophosphoesterase 1

    See identical proteins and their annotated locations for NP_001101905.1

    Status: PROVISIONAL

    Source sequence(s)
    BC162043
    UniProtKB/Swiss-Prot
    B1WC86
    Related
    ENSRNOP00000025164.5, ENSRNOT00000025164.6
    Conserved Domains (2) summary
    cd08165
    Location:70 → 327
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:67 → 303
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    63033329..63051461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096982.2 → XP_038952910.1  metallophosphoesterase 1 isoform X4

    Conserved Domains (1) summary
    cd08165
    Location:70 → 301
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  2. XM_039096981.2 → XP_038952909.1  metallophosphoesterase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y647
    Conserved Domains (1) summary
    cd08165
    Location:70 → 302
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  3. XM_006254881.5 → XP_006254943.1  metallophosphoesterase 1 isoform X2

    Conserved Domains (2) summary
    cd08165
    Location:70 → 326
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:67 → 302
    Metallophos; Calcineurin-like phosphoesterase

  4. XM_017600999.3 → XP_017456488.1  metallophosphoesterase 1 isoform X5

  5. XM_063277483.1 → XP_063133553.1  metallophosphoesterase 1 isoform X2

  6. XM_006254879.5 → XP_006254941.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_006254941.1

    UniProtKB/Swiss-Prot
    B1WC86
    Conserved Domains (2) summary
    cd08165
    Location:70 → 327
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain
    pfam00149
    Location:67 → 303
    Metallophos; Calcineurin-like phosphoesterase

  7. XM_039096983.2 → XP_038952911.1  metallophosphoesterase 1 isoform X6

    Conserved Domains (1) summary
    cl13995
    Location:70 → 175
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1WC86.1 GenPept UniProtKB/Swiss-Prot:B1WC86

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