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Usp34 ubiquitin specific peptidase 34 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360990, updated on 2-Nov-2024

Summary

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Official Symbol
Usp34provided by RGD
Official Full Name
ubiquitin specific peptidase 34provided by RGD
Primary source
RGD:1565181
See related
EnsemblRapid:ENSRNOG00000051889 AllianceGenome:RGD:1565181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein K48-linked deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 276.9), Brain (RPKM 239.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Usp34 in Genome Data Viewer
Location:
14q22
Exon count:
81
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101487110..101677519)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97285799..97476376)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108060653..108264706)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene telomerase RNA component interacting Rnase like 1 Neighboring gene uncharacterized LOC108352815 Neighboring gene similar to human chromosome 2 open reading frame 74 Neighboring gene activator of HSP90 ATPase homolog 2 Neighboring gene deoxycytidine kinase, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. Lui TT, et al. Mol Cell Biol, 2011 May. PMID 21383061, Free PMC Article
  2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 34
Names
ubiquitin specific protease 34
NP_001258125.1
XP_038948159.1
XP_038948160.1
XP_038948161.1
XP_038948162.1
XP_063129477.1
XP_063129478.1
XP_063129479.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271196.2 → NP_001258125.1  ubiquitin carboxyl-terminal hydrolase 34

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/TrEMBL
    A0A8I5ZVK3, A0A8I6GH56
    Related
    ENSRNOP00000081701.1, ENSRNOT00000110345.2
    Conserved Domains (2) summary
    cd02659
    Location:1933 → 2282
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1935 → 2277
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    101487110..101677519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039092231.2 → XP_038948159.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GH56
    Conserved Domains (2) summary
    cd02659
    Location:1934 → 2283
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12030
    Location:2401 → 2734
    DUF3517; Domain of unknown function (DUF3517)

  2. XM_039092233.2 → XP_038948161.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GH56
    Related
    ENSRNOP00000088502.1, ENSRNOT00000110300.2
    Conserved Domains (2) summary
    cd02659
    Location:1934 → 2283
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12030
    Location:2401 → 2734
    DUF3517; Domain of unknown function (DUF3517)

  3. XM_039092232.2 → XP_038948160.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GH56
    Conserved Domains (2) summary
    cd02659
    Location:1922 → 2271
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12030
    Location:2389 → 2722
    DUF3517; Domain of unknown function (DUF3517)

  4. XM_063273407.1 → XP_063129477.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZT30
    Related
    ENSRNOP00000081582.2, ENSRNOT00000094041.2

  5. XM_063273409.1 → XP_063129479.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X7

  6. XM_039092234.2 → XP_038948162.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X5

    UniProtKB/TrEMBL
    A6JQ71
    Conserved Domains (2) summary
    cd02659
    Location:1735 → 2084
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam12030
    Location:2202 → 2535
    DUF3517; Domain of unknown function (DUF3517)

  7. XM_063273408.1 → XP_063129478.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X6

Nucleotide Protein Strain
Heading Accession and Version

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