U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Uchl5 ubiquitin C-terminal hydrolase L5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360853, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Uchl5provided by RGD
Official Full Name
ubiquitin C-terminal hydrolase L5provided by RGD
Primary source
RGD:1305414
See related
EnsemblRapid:ENSRNOG00000003545 AllianceGenome:RGD:1305414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type deubiquitinase activity; endopeptidase inhibitor activity; and proteasome binding activity. Predicted to be involved in several processes, including brain development; positive regulation of smoothened signaling pathway; and regulation of nucleobase-containing compound metabolic process. Part of cytosolic proteasome complex. Orthologous to human UCHL5 (ubiquitin C-terminal hydrolase L5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 153.5), Thymus (RPKM 109.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Uchl5 in Genome Data Viewer
Location:
13q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (58070947..58106825)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (55520722..55556503)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (60568102..60603812)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene cell division cycle 73 Neighboring gene uncharacterized LOC108352545 Neighboring gene glutaredoxin 2 Neighboring gene uncharacterized LOC120096268 Neighboring gene small Cajal body-specific RNA 18B Neighboring gene Ro60, Y RNA binding protein Neighboring gene uncharacterized LOC103691931 Neighboring gene uncharacterized LOC102551374

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Proteomic analysis of testicular ischemia-reperfusion injury in rats. Ouh IO, et al. J Vet Med Sci, 2014 Mar. PMID 24189580, Free PMC Article
  2. Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor-β receptor I expression and hypertrophy in mesangial cells. Ko YM, et al. Arch Biochem Biophys, 2013 Jul 15. PMID 23500140
  3. Chronic ethanol feeding affects proteasome-interacting proteins. Bousquet-Dubouch MP, et al. Proteomics, 2009 Jul. PMID 19609968, Free PMC Article
  4. Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Matilainen O, et al. Cell Rep, 2013 Jun 27. PMID 23770237
  5. Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Koulich E, et al. Mol Biol Cell, 2008 Mar. PMID 18162577, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables proteasome binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in forebrain morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in lateral ventricle development ISO
Inferred from Sequence Orthology
more info
  
involved_in midbrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA strand elongation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ino80 complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase isozyme L5
Names
ubiquitin carboxyl-terminal esterase L5
ubiquitin carboxyl-terminal hydrolase L5
NP_001380778.1
NP_001380779.1
NP_001380780.1
XP_038946829.1
XP_063128542.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393849.1 → NP_001380778.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2K2A5, A0A8I6GL10, A6ICP4
    Related
    ENSRNOP00000102415.1, ENSRNOT00000140387.1
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:264 → 309
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  2. NM_001393850.1 → NP_001380779.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2K2A5
    Related
    ENSRNOP00000100152.1, ENSRNOT00000150460.1
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:263 → 308
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  3. NM_001393851.1 → NP_001380780.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A0G2K2A5
    Related
    ENSRNOP00000094138.2, ENSRNOT00000098889.2
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:235 → 271
    UCH_C; Ubiquitin carboxyl-terminal hydrolases

  4. NM_001429622.1 → NP_001416551.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  5. NM_001429623.1 → NP_001416552.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RNA

  1. NR_172020.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

  2. NR_190751.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    58070947..58106825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272472.1 → XP_063128542.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X2

  2. XM_039090901.2 → XP_038946829.1  ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2A5, Q5HZY3
    Related
    ENSRNOP00000004881.4, ENSRNOT00000004881.8
    Conserved Domains (2) summary
    cd02255
    Location:8 → 223
    Peptidase_C12; Cysteine peptidase C12 contains ubiquitin carboxyl-terminal hydrolase (UCH) families L1, L3, L5 and BAP1
    pfam18031
    Location:264 → 309
    UCH_C; Ubiquitin carboxyl-terminal hydrolases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools