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Kdsr 3-ketodihydrosphingosine reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 360833, updated on 17-Aug-2024

Summary

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Official Symbol
Kdsrprovided by RGD
Official Full Name
3-ketodihydrosphingosine reductaseprovided by RGD
Primary source
RGD:1307775
See related
EnsemblRapid:ENSRNOG00000002781 AllianceGenome:RGD:1307775
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fvt1
Summary
Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Orthologous to human KDSR (3-ketodihydrosphingosine reductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 161.9), Liver (RPKM 92.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kdsr in Genome Data Viewer
Location:
13p11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (23374101..23408779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (22862117..22894118, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (26779386..26812271, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene BCL2, apoptosis regulator Neighboring gene uncharacterized LOC120096229 Neighboring gene uncharacterized LOC134481474 Neighboring gene uncharacterized LOC134481473 Neighboring gene vacuolar protein sorting 4 homolog B Neighboring gene serpin family B member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FVT-1, a novel human transcription unit affected by variant translocation t(2;18)(p11;q21) of follicular lymphoma. Rimokh R, et al. Blood, 1993 Jan 1. PMID 8417785
  2. Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma. Boyden LM, et al. Am J Hum Genet, 2017 Jun 1. PMID 28575652, Free PMC Article
  3. FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane. Kihara A, et al. J Biol Chem, 2004 Nov 19. PMID 15328338
  4. Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites. Fukatsu K, et al. J Biol Chem, 2004 Nov 19. PMID 15364918
  5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3-dehydrosphinganine reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-dehydrosphinganine reductase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 3-keto-sphinganine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 3-keto-sphinganine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 3-keto-sphinganine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in sphingolipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
3-ketodihydrosphingosine reductase
Names
follicular lymphoma variant translocation 1
NP_001101812.1
XP_038946804.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108342.1 → NP_001101812.1  3-ketodihydrosphingosine reductase

    See identical proteins and their annotated locations for NP_001101812.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474000
    UniProtKB/TrEMBL
    A0A8I6AMK1, A6JSU9, A6JSV0
    Related
    ENSRNOP00000085720.1, ENSRNOT00000099177.2
    Conserved Domains (1) summary
    cd08939
    Location:32 → 268
    KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    23374101..23408779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090876.2 → XP_038946804.1  3-ketodihydrosphingosine reductase isoform X1

    UniProtKB/TrEMBL
    A6JSU9, D3Z9P1
    Related
    ENSRNOP00000093847.2, ENSRNOT00000099271.2
    Conserved Domains (1) summary
    cd08939
    Location:32 → 258
    KDSR-like_SDR_c; 3-ketodihydrosphingosine reductase (KDSR) and related proteins, classical (c) SDR
Nucleotide Protein Strain
Heading Accession and Version

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