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Naa25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit [ Rattus norvegicus (Norway rat) ]

Gene ID: 360811, updated on 2-Nov-2024

Summary

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Official Symbol
Naa25provided by RGD
Official Full Name
N(alpha)-acetyltransferase 25, NatB auxiliary subunitprovided by RGD
Primary source
RGD:1305685
See related
EnsemblRapid:ENSRNOG00000001350 AllianceGenome:RGD:1305685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mdm20; LRRGT00164; RGD1305685
Summary
Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Located in cytoplasm. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 105.6), Muscle (RPKM 101.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Naa25 in Genome Data Viewer
Location:
12q16
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40758909..40811192, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (35098256..35150498, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (40628005..40680421, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 116 Neighboring gene a disintegrin and metallopeptidase domain 1b Neighboring gene uncharacterized LOC120095847 Neighboring gene endoplasmic reticulum protein 29 Neighboring gene 40S ribosomal protein S27-like Neighboring gene 40S ribosomal protein S20-like Neighboring gene HECT domain E3 ubiquitin protein ligase 4 Neighboring gene TRAF type zinc finger domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mdm20 stimulates polyQ aggregation via inhibiting autophagy through Akt-Ser473 phosphorylation. Yasuda K, et al. PLoS One, 2013. PMID 24358196, Free PMC Article
  2. Spatio-temporal expression pattern of the NatB complex, Nat5/Mdm20 in the developing mouse brain: implications for co-operative versus non-co-operative actions of Mdm20 and Nat5. Ohyama K, et al. Gene Expr Patterns, 2012 Jan-Feb. PMID 22101279
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acetyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of NatB complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatB complex IEA
Inferred from Electronic Annotation
more info
  
part_of NatB complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Names
N-terminal acetyltransferase B complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
liver regeneration-related protein LRRGT00164
mitochondrial distribution and morphology protein 20
natB complex subunit MDM20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413582.1 → NP_001400511.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A0G2K9Q3, A6J1F1
    Related
    ENSRNOP00000075085.2, ENSRNOT00000080418.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    40758909..40811192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271535.1 → XP_063127605.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X1

    Related
    ENSRNOP00000049175.1, ENSRNOT00000048984.4

  2. XM_039089597.2 → XP_038945525.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

    UniProtKB/TrEMBL
    A6J1F2
    Conserved Domains (2) summary
    sd00006
    Location:47 → 73
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:264 → 553
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

  3. XM_039089598.2 → XP_038945526.1  N-alpha-acetyltransferase 25, NatB auxiliary subunit isoform X2

    UniProtKB/TrEMBL
    A6J1F2
    Conserved Domains (2) summary
    sd00006
    Location:47 → 73
    TPR; TPR repeat [structural motif]
    pfam09797
    Location:264 → 553
    NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit

RNA

  1. XR_005491649.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047900.1: Suppressed sequence

    Description
    NM_001047900.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6QI44.1 GenPept UniProtKB/Swiss-Prot:Q6QI44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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